PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity (Q28575407)

31 January 2017

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1 February 2020

title

PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity (English)

2 references

31 January 2017

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1 February 2020

1 reference

3

1 reference

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1 February 2020

Antonio Vidal-Puig

5

1 reference

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1 February 2020

David J Wyllie

6

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1 February 2020

Giles E. Hardingham

7

1 reference

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1 February 2020

author name string

Clare Puddifoot

1

2 references

31 January 2017

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1 February 2020

Marc-Andre Martel

2

2 references

31 January 2017

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1 February 2020

Alberto Camacho

4

2 references

31 January 2017

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1 February 2020

language of work or name

English

0 references

publication date

1 May 2012

1 reference

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1 February 2020

published in

Journal of Neuroscience

2 references

31 January 2017

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1 February 2020

volume

32

2 references

31 January 2017

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1 February 2020

issue

20

2 references

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1 February 2020

page(s)

6995-7000

1 reference

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PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

1 February 2020

cites work

1 reference

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Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

17 March 2017

1 reference

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PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

7 April 2017

1 reference

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Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease

7 April 2017

1 reference

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Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

29 September 2017

1 reference

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Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

29 September 2017

1 reference

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Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.

29 September 2017

1 reference

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Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

29 September 2017

1 reference

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Protective effects of peroxisome proliferator-activated receptors gamma coactivator-1alpha against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia.

29 September 2017

1 reference

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The biology of PGC-1α and its therapeutic potential

29 September 2017

1 reference

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses.

29 September 2017

1 reference

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Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

27 November 2018

1 reference

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NMDA receptor dependent PGC-1alpha up-regulation protects the cortical neuron against oxygen-glucose deprivation/reperfusion injury

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359835

10.1523/JNEUROSCI.6407-11.2012

27 November 2018

Identifiers

DOI

2 references

31 January 2017

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1 February 2020

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1 February 2020

2 references

31 January 2017