Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling (Q28586249)

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English	Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling	scientific journal article

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scholarly article

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31 January 2017

Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling (English)

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31 January 2017

Inhibitor of kappaB kinase gamma

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GOA release 2020-03-11

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based on heuristic

inferred from title

8

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object named as

Hidekatsu Iha

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author name string

Karen V. Kibler

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31 January 2017

Venkat R. K. Yedavalli

3

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31 January 2017

Jean-Marie Peloponese

4

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31 January 2017

Kerstin Haller

5

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31 January 2017

Akiko Miyazato

6

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31 January 2017

Takefumi Kasai

7

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31 January 2017

language of work or name

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publication date

4 December 2003

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31 January 2017

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31 January 2017

22

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55

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31 January 2017

8912–8923

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31 January 2017

NEMO trimerizes through its coiled-coil C-terminal domain

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Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies

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IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.

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IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein

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Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera

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Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: mitotic checkpoint abrogation and NF-kappaB activation

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Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function

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Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

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NF-kappaB in cancer: from innocent bystander to major culprit

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Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors

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CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein

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NF-kappaB regulation in the immune system

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Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation

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Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization

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Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation

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Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

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Sites on FIP-3 (NEMO/IKKgamma) essential for its phosphorylation and NF-kappaB modulating activity

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I kappa B proteins: structure, function and regulation

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Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK.

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Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

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Regulation of the NF-kappaB activation pathway by isolated domains of FIP3/IKKgamma, a component of the IkappaB-alpha kinase complex

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Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease

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HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

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A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis

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Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

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NEMO/IKK gamma: linking NF-kappa B to human disease.

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Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

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Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.

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Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia

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The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation

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NF-kappaB at the crossroads of life and death

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Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B

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IKK1-deficient mice exhibit abnormal development of skin and skeleton

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Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex

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Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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Predicting coiled coils from protein sequences

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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

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Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

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IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation.

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NF-kappaB as a therapeutic target in cancer

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Perspectives on anti-HER monoclonal antibodies

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Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

1 reference

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7 January 2021

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Signal transduction. Docking IkappaB kinases.

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NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

1 reference

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7 January 2021

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Limb and skin abnormalities in mice lacking IKKalpha

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7 January 2021

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Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

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7 January 2021

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Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation

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7 January 2021

based on heuristic

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IKKgamma /NEMO facilitates the recruitment of the IkappaB proteins into the IkappaB kinase complex

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7 January 2021

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control

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7 January 2021

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

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Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

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10.1038/SJ.ONC.1207058

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31 January 2017

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31 January 2017

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