Vav GEFs are required for beta2 integrin-dependent functions of neutrophils (Q28590406)

21 June 2017

title

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils (English)

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Intercellular adhesion molecule 1

21 June 2017

main subject

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Ras homolog family member A

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Rac family small GTPase 1

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Vav 1 oncogene

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Rac family small GTPase 2

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Integrin beta 2

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Vav 3 oncogene

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Cell division cycle 42

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10

Joan S Brugge

1 reference

21 June 2017

Xavier Cullere

2

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21 June 2017

Timothy Olson

3

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21 June 2017

Bin Zhang

5

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21 June 2017

Klaus Ley

7

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21 June 2017

Wojciech Swat

8

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21 June 2017

Tanya Mayadas

9

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21 June 2017

M Angelica Martinez Gakidis

1

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21 June 2017

Julie L Wilsbacher

4

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21 June 2017

Sheri L Moores

6

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21 June 2017

language of work or name

English

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publication date

12 July 2004

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21 June 2017

number of pages

10

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inferred from page(s)

published in

Journal of Cell Biology

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21 June 2017

volume

166

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21 June 2017

issue

2

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21 June 2017

page(s)

273-282

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P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

21 June 2017

cites work

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Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

17 March 2017

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Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands

17 March 2017

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Vav2 is required for cell spreading

17 March 2017

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Vav family proteins couple to diverse cell surface receptors

17 March 2017

1 reference

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Regulatory and signaling properties of the Vav family

17 March 2017

1 reference

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Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

17 March 2017

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Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

17 March 2017

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

17 March 2017

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

17 March 2017

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Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases

17 March 2017

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Activation of Rac and Cdc42 by integrins mediates cell spreading

7 April 2017

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

7 April 2017

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Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

7 April 2017

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29 September 2017

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Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

29 September 2017

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Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

29 September 2017

1 reference

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Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again

29 September 2017

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Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods.

29 September 2017

1 reference

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Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

29 September 2017

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Intercellular adhesion molecule-1 is required for chemoattractant-induced leukocyte adhesion in resting, but not inflamed, venules in vivo

29 September 2017

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Rho family proteins and regulation of the actin cytoskeleton

29 September 2017

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Adenosine diphosphate (ADP)-ribosylation of the guanosine triphosphatase (GTPase) rho in resting peripheral blood human T lymphocytes results in pseudopodial extension and the inhibition of T cell activation

29 September 2017

1 reference

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Integrin-mediated signals regulated by members of the rho family of GTPases

29 September 2017

1 reference

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Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes

29 September 2017

1 reference

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Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

29 September 2017

1 reference

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Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells.

29 September 2017

1 reference

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Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

29 September 2017

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LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice

29 September 2017

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Sequential contribution of L- and P-selectin to leukocyte rolling in vivo

29 September 2017

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Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins

29 September 2017

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A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

29 September 2017

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Analysis of G-protein-coupled receptor dimerization following chemokine signaling

3 June 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

Syk is required for integrin signaling in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200404166

Impairment of neutrophil emigration in CD18-null mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172310

Integrin-dependent tyrosine phosphorylation and growth regulation by Vav

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172310

Orientation chamber in chemotaxis

27 November 2018

1 reference

12 December 2020

A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation

1 reference

12 December 2020

Role of Rho in chemoattractant-activated leukocyte adhesion through integrins

1 reference

12 December 2020

Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets

1 reference

12 December 2020

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1 reference

12 December 2020

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

12 December 2020

Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

1 reference

12 December 2020

Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200404166

1 reference

21 June 2017

0 references

1 reference