Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter (Q28593503)

Runt-related transcription factor 1

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Runt related transcription factor 2

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Catenin (cadherin associated protein), beta 1

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Journal of Biological Chemistry

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Rachel A. Kahler

1

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31 January 2017

Jennifer J. Westendorf

series ordinal

2

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31 January 2017

language of work or name

English

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publication date

4 April 2003

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31 January 2017

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31 January 2017

278

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31 January 2017

14

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31 January 2017

11937–11944

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31 January 2017

Cbfa1: a molecular switch in osteoblast biology

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https://api.crossref.org/works/10.1074%2FJBC.M211443200

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Runx2, a multifunctional transcription factor in skeletal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

TCF transcription factors, mediators of Wnt-signaling in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Identification of c-MYC as a target of the APC pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

ovo/svb integrates Wingless and DER pathways to control epidermis differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Drosophila segment borders result from unilateral repression of hedgehog activity by wingless signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

The promise and perils of Wnt signaling through beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

High bone density due to a mutation in LDL-receptor-related protein 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Inhibitory transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Transcriptional coregulators in development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Stabilization of beta-catenin by genetic defects in melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Wnt signalling shows its versatility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

A transcriptional response to Wnt protein in human embryonic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Localization of the gene causing autosomal dominant osteopetrosis type I to chromosome 11q12-13

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Characterization of the upstream mouse Cbfa1/Runx2 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

The notch intracellular domain can function as a coactivator for LEF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Functional analysis of DNA bending and unwinding by the high mobility group domain of LEF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200

Neither straight nor narrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211443200