Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice (Q28594703)

GOA release 2020-03-11

reactive oxygen species

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Liang-Jun Yan

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author name string

Marzia Scortegagna

1

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31 January 2017

Kan Ding

2

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31 January 2017

Yavuz Oktay

3

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31 January 2017

Arti Gaur

4

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31 January 2017

Frederick Thurmond

5

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31 January 2017

Brett T. Marck

7

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31 January 2017

Alvin M. Matsumoto

8

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31 January 2017

John M. Shelton

9

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31 January 2017

James A. Richardson

10

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31 January 2017

Michael J. Bennett

11

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31 January 2017

Joseph A. Garcia

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

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31 January 2017

language of work or name

English

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publication date

1 December 2003

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31 January 2017

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31 January 2017

35

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31 January 2017

4

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31 January 2017

331–340

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31 January 2017

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7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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7 January 2021

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

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7 January 2021

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

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7 January 2021

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

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7 January 2021

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

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7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

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7 January 2021

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

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7 January 2021

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

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7 January 2021

Ragged red fibers in normal aging and inflammatory myopathy

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7 January 2021

Mitochondrial diseases in man and mouse

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7 January 2021

Measurement of superoxide radical and hydrogen peroxide production in isolated cells and subcellular organelles

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7 January 2021

Expression of stress response genes GADD153, c-jun, and heme oxygenase-1 in H2O2- and O2-resistant fibroblasts

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7 January 2021

Transcriptional induction of metallothionein-I and -II genes in the livers of Cu,Zn-superoxide dismutase knockout mice.

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7 January 2021

Tumor necrosis factor-alpha selectively induces MnSOD expression via mitochondria-to-nucleus signaling, whereas interleukin-1beta utilizes an alternative pathway

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7 January 2021

Peroxynitrite modulates MnSOD gene expression in lung epithelial cells

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7 January 2021

Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.

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7 January 2021

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

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7 January 2021

Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice

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7 January 2021

A quantitative genetic analysis of tissue-specific catalase activity in Mus musculus

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7 January 2021

Tissue-specific developmental regulation of superoxide dismutase (SOD-1 and SOD-2) activities in genetic strains of mice.

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7 January 2021

Characterization of the murine gene encoding Aop2 (antioxidant protein 2) and identification of two highly related genes.

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7 January 2021

Mitochondrial respiratory-chain diseases

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7 January 2021

Primary defect of juvenile visceral steatosis (jvs) mouse with systemic carnitine deficiency is probably in renal carnitine transport system

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7 January 2021

Mitochondrial abnormalities of muscle tissue in mice with juvenile visceral steatosis associated with systemic carnitine deficiency

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7 January 2021

Mitochondrial abnormalities in a murine model of primary carnitine deficiency. Systemic pathology and trial of replacement therapy

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7 January 2021

Antioxidant changes in the hypertrophied heart due to energy metabolic disorder

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7 January 2021

A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator

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7 January 2021

Mitochondrial disease in mouse results in increased oxidative stress

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7 January 2021

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

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7 January 2021

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

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7 January 2021

Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant

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7 January 2021

Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice

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7 January 2021

Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

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7 January 2021

Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration.

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7 January 2021

Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells

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7 January 2021

Dopamine- and L-beta-3,4-dihydroxyphenylalanine hydrochloride (L-Dopa)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells. Effects of oxidative stress and antioxidative factors

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7 January 2021

Hyperglycemic switch from mitochondrial nitric oxide to superoxide production in endothelial cells

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7 January 2021

Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain

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7 January 2021

Lactate and PO2 modulate superoxide anion production in bovine cardiac myocytes: potential role of NADH oxidase

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7 January 2021

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

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7 January 2021

Hypoxic modulation of manganese superoxide dismutase promoter activity and gene expression in lung epithelial cells

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7 January 2021

Transcription regulation of human manganese superoxide dismutase gene

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7 January 2021

Regulation of gene expression by reactive oxygen

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7 January 2021

Oxygen sensing and molecular adaptation to hypoxia

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7 January 2021