Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 (Q28609687)

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Rho GTPases and their effector proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Conformational switch and role of phosphorylation in PAK activation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

The Ste20 group kinases as regulators of MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Leucine zipper-mediated homodimerization of the p21-activated kinase-interacting factor, beta Pix. Implication for a role in cytoskeletal reorganization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

The p21Rac/Cdc42-activated kinases (PAKs).

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Structure of Cdc42 bound to the GTPase binding domain of PAK

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Identification of the Nef-associated kinase as p21-activated kinase 2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

The Akt proto-oncogene links Ras to Pak and cell survival signals

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Delineation of the Cdc42/Rac-binding domain of p21-activated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Genetic evidence for Pak1 autoinhibition and its release by Cdc42.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2

7 January 2021