Inferring processes underlying B-cell repertoire diversity (Q28640380)

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Zachary Sethna

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Quentin Marcou

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Thierry Mora

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Aleksandra M Walczak

Philosophical Transactions of the Royal Society B

6

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language of work or name

English

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publication date

5 September 2015

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published in

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volume

370

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issue

1676

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page(s)

20140243

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cites work

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Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development

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The inference of antigen selection on Ig genes

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Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences.

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Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells

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Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

3 June 2018

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CDR3 length in antigen-specific immune receptors

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Development of the expressed Ig CDR-H3 repertoire is marked by focusing of constraints in length, amino acid use, and charge that are first established in early B cell progenitors

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The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation

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Strong intrinsic biases towards mutation and conservation of bases in human IgVH genes during somatic hypermutation prevent statistical analysis of antigen selection

21 January 2018

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The Targeting of Somatic Hypermutation Closely Resembles That of Meiotic Mutation

21 January 2018

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Hypermutation at A-T base pairs: the A nucleotide replacement spectrum is affected by adjacent nucleotides and there is no reverse complementarity of sequences flanking mutated A and T nucleotides.

21 January 2018

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IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth.

21 January 2018

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Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes

27 November 2018

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Many human peripheral VH5-expressing IgM+ B cells display a unique heavy-chain rearrangement

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26194757

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1098/RSTB.2014.0243

1 reference

1 reference

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924211

1 reference

1 reference

924211

PubMed publication ID

26194757

1 reference