Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity (Q28729760)

1

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N Pollak

2

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O Seifert

3

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K Wahl

4

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K Hanak

5

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A Vogel

6

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A K Nussler

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D Göttsch

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S Münkel

9

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H Bantel

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R E Kontermann

"Diabodies": small bivalent and bispecific antibody fragments

11

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language of work or name

English

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publication date

12 April 2012

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published in

Cell Death and Disease

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volume

3

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issue

4

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page(s)

e295

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cites work

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Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

3 June 2018

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Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs.

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Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL.

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A novel AML-selective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability

3 June 2018

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Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2.

21 January 2018

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Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts.

21 January 2018

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Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

21 January 2018

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The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum

21 January 2018

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Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

21 January 2018

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12 December 2020

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

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12 December 2020

Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative

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12 December 2020

Loss of CD95 expression is linked to most but not all p53 mutants in European hepatocellular carcinoma

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12 December 2020

TNF-Selectokine: a novel prodrug generated for tumor targeting and site-specific activation of tumor necrosis factor

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12 December 2020

Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells

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TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies

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12 December 2020

Identifiers

DOI

10.1038/CDDIS.2012.29

1 reference

1 reference

1 reference

PubMed publication ID

22495350

1 reference