Targeting death and decoy receptors of the tumour-necrosis factor superfamily (Q34791120)

4 August 2017

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title

Targeting death and decoy receptors of the tumour-necrosis factor superfamily (English)

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4 August 2017

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Avi Ashkenazi

1

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PubMed ID

12189384

4 August 2017

language of work or name

English

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publication date

1 June 2002

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4 August 2017

Nature Reviews Cancer

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4 August 2017

2

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4 August 2017

420-430

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4 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrc821

4 August 2017

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Involvement of APO2 ligand/TRAIL in activation-induced death of Jurkat and human peripheral blood T cells

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Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5

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Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL

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31 March 2020

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TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells

31 March 2020

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31 March 2020

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Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

31 March 2020

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Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

31 March 2020

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Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4

31 March 2020

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Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

31 March 2020

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Monoclonal antibody-mediated tumor regression by induction of apoptosis.

31 March 2020

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Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

31 March 2020

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Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

31 March 2020

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Avoiding premature apoptosis of normal epidermal cells

31 March 2020

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The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation

31 March 2020

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A matter of life and cell death

31 March 2020

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Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types

31 March 2020

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Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1

31 March 2020

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Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster

31 March 2020

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Amplification and expression of a decoy receptor for fas ligand (DcR3) in virus (EBV or HTLV-I) associated lymphomas

31 March 2020

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Apoptosis by death factor

31 March 2020

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31 March 2020

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Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein

31 March 2020

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The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors

31 March 2020

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Fas transduces activation signals in normal human T lymphocytes

31 March 2020

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Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

31 March 2020

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The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells

31 March 2020

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

31 March 2020

1 reference

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

31 March 2020

1 reference

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

31 March 2020

1 reference

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

31 March 2020

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

31 March 2020

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Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

31 March 2020

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Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

31 March 2020

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

1 reference

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

Role of BAX in the apoptotic response to anticancer agents

31 March 2020

1 reference

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

31 March 2020

1 reference

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

31 March 2020

1 reference

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

31 March 2020

1 reference

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

31 March 2020

1 reference

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

31 March 2020

1 reference

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

31 March 2020

1 reference

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

31 March 2020

1 reference

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

31 March 2020

1 reference

Caspase-10 is an initiator caspase in death receptor signaling

31 March 2020

1 reference

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

31 March 2020

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TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

31 March 2020

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Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95

31 March 2020

1 reference

Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B

31 March 2020

1 reference

A death-domain-containing receptor that mediates apoptosis

31 March 2020

1 reference

Identification and functional characterization of DR6, a novel death domain-containing TNF receptor

31 March 2020

1 reference

Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice

31 March 2020

1 reference

Phase II studies of recombinant human tumor necrosis factor alpha in patients with malignant disease: a summary of the Southwest Oncology Group experience

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRC821

1 reference

PubMed ID

12189384

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12189384