Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies (Q28821982)

1

0 references

Jan Stracke

2

0 references

Stefan Dengl

3

0 references

Alexander Knaupp

4

0 references

Jan Pollmann

5

0 references

Johannes Buchner

6

0 references

Tilman Schlothauer

7

0 references

language of work or name

English

0 references

publication date

2016

1 reference

Creative Commons Attribution-NonCommercial 3.0 Unported

published in

Monoclonal Antibodies

0 references

volume

8

0 references

issue

8

0 references

page(s)

1525-1535

0 references

copyright license

start time

9 September 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

Antibodies to watch in 2015

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Identification of potential sites for tryptophan oxidation in recombinant antibodies using tert-butylhydroperoxide and quantitative LC-MS

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Broadly neutralizing anti-hepatitis B virus antibody reveals a complementarity determining region H3 lid-opening mechanism

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

XGFR*, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cancer

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Characterization of asparagine 330 deamidation in an Fc-fragment of IgG1 using cation exchange chromatography and peptide mapping.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

A novel glycoengineered bispecific antibody format for targeted inhibition of epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor type I (IGF-1R) demonstrating unique molecular properties

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Toward aggregation-resistant antibodies by design

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

N-terminal truncation of an isolated human IgG1 CH2 domain significantly increases its stability and aggregation resistance

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Forced degradation of therapeutic proteins.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Engineering the variable region of therapeutic IgG antibodies.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Separation of oxidized variants of a monoclonal antibody by anion-exchange

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Post-translational modifications differentially affect IgG1 conformation and receptor binding.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Effect of methionine oxidation on the structural properties, conformational stability, and aggregation of immunoglobulin light chain LEN.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Functional variability of antibodies upon oxidative processes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Post-translational modifications of recombinant proteins: significance for biopharmaceuticals

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Heterogeneity of monoclonal antibodies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Recombinant therapeutic monoclonal antibodies: mechanisms of action in relation to structural and functional duality.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Analysis of post-translational modifications in recombinant monoclonal antibody IgG1 by reversed-phase liquid chromatography/mass spectrometry.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Impact of methionine oxidation on the binding of human IgG1 to Fc Rn and Fc gamma receptors

3 June 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Analytical protein a chromatography as a quantitative tool for the screening of methionine oxidation in monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Effect of individual Fc methionine oxidation on FcRn binding: Met252 oxidation impairs FcRn binding more profoundly than Met428 oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Effect of methionine oxidation of a recombinant monoclonal antibody on the binding affinity to protein A and protein G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Structural effect of deglycosylation and methionine oxidation on a recombinant monoclonal antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Identification of a single tryptophan residue as critical for binding activity in a humanized monoclonal antibody against respiratory syncytial virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

HIC resolution of an IgG1 with an oxidized Trp in a complementarity determining region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Asparagine deamidation: pH-dependent mechanism from density functional theory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Asparagine deamidation dependence on buffer type, pH, and temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Influence of pH, buffer species, and storage temperature on physicochemical stability of a humanized monoclonal antibody LA298.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Identification and characterization of oxidation and deamidation sites in monoclonal rat/mouse hybrid antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Human antibody Fc deamidation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Method to differentiate asn deamidation that occurred prior to and during sample preparation of a monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Characterization of a unique IgG1 mAb CEX profile by limited Lys-C proteolysis/CEX separation coupled with mass spectrometry and structural analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Identification of deamidation and isomerization sites on pharmaceutical recombinant antibody using H(2)(18)O.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

The physical stability of the recombinant tuberculosis fusion antigens h1 and h56.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1231277

Heterogeneity of recombinant antibodies: linking structure to function

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Identification of multiple sources of charge heterogeneity in a recombinant antibody.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5098445

Comparison of methionine oxidation in thermal stability and chemically stressed samples of a fully human monoclonal antibody

26 November 2018

1 reference

12 December 2020

Expression, refolding, and ferritin-binding activity of the isolated VL-domain of monoclonal antibody F11

1 reference

12 December 2020

Monoclonal antibody heterogeneity analysis and deamidation monitoring with high-performance cation-exchange chromatofocusing using simple, two component buffer systems

1 reference

12 December 2020

Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization

1 reference

12 December 2020

Antioxidants for prevention of methionine oxidation in recombinant monoclonal antibody HER2

1 reference

12 December 2020

10.1080/19420862.2016.1231277

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

27612038

1 reference