Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14 (Q28910355)

GOA release 2020-03-11

insulin receptor

1 reference

negative regulation of insulin receptor signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Rafael S. Depetris

1

1 reference

7 March 2017

Junjie Hu

2

1 reference

7 March 2017

Ilana Gimpelevich

3

1 reference

7 March 2017

Lowenna J. Holt

4

1 reference

7 March 2017

Roger J. Daly

5

1 reference

7 March 2017

Stevan R. Hubbard

Kinase activation through dimerization by human SH2-B

6

1 reference

7 March 2017

28 October 2005

1 reference

7 March 2017

1 reference

7 March 2017

20

1 reference

7 March 2017

2

1 reference

7 March 2017

325–333

1 reference

7 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

The PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signaling

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Identification of the rat adapter Grb14 as an inhibitor of insulin actions

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Improved methods for building protein models in electron density maps and the location of errors in these models

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Grb10 and Grb14: enigmatic regulators of insulin action--and more?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Increased adipose tissue expression of Grb14 in several models of insulin resistance

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-kinase-dependent signalling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Modular peptide recognition domains in eukaryotic signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526137

Processing of X-ray diffraction data collected in oscillation mode

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16246733

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2005.09.001

1 reference

1779

1779

1 reference

1 reference

1 reference