insulin receptor (Q422579)

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mammalian protein found in Homo sapiens
  • IR
  • INSR
  • uniprot:P06213
  • Receptor, Insulin
edit
Language Label Description Also known as
English
insulin receptor
mammalian protein found in Homo sapiens
  • IR
  • INSR
  • uniprot:P06213
  • Receptor, Insulin

Statements

part of
molecular function
protein binding
determination method
IPI
36 references
retrieved
8 April 2019
stated in
Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B
GOA
curator
UniProt
UniProt protein ID
P06213
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain
GOA
curator
UniProt
UniProt protein ID
P06213
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
A fluorescent indicator for tyrosine phosphorylation-based insulin signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
An enzyme-linked immunosorbent assay to measure insulin receptor dephosphorylation by PTP1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Monitoring the activation state of insulin/insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of protein tyrosine phosphatase 1B by sumoylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Comparative analysis of the signaling capabilities of the insulin receptor-related receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
retrieved
8 April 2019
stated in
The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IPI
cell component
biological process
insulin receptor signaling pathway
determination method
IDA
IEA
ISS
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
TAS
retrieved
8 April 2019
stated in
Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IEA
retrieved
8 April 2019
stated in
Ligand-binding properties of the two isoforms of the human insulin receptor
GOA
curator
UniProt
UniProt protein ID
P06213
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IDA
retrieved
8 April 2019
stated in
Insulin receptor: evidence that it is a protein kinase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IDA
retrieved
8 April 2019
stated in
A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213
determination method
IDA
Gene Atlas image
PBB GE INSR 213792 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

NL CR AUT ID
ph121176
subject named as
inzulinové receptory
0 references
MeSH descriptor ID
D011972
subject named as
Receptor, Insulin
0 references
PDB structure ID
 
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