Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK (Q28910436)

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English	Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK	scientific journal article

Statements

scholarly article

1 reference

7 March 2017

Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK (English)

1 reference

7 March 2017

0 references

RELA proto-oncogene, NF-kB subunit

1 reference

GOA release 2020-03-11

Integrin linked kinase

1 reference

GOA release 2020-03-11

LIM zinc finger domain containing 1

1 reference

GOA release 2020-03-11

Thymosin beta 4 X-linked

1 reference

GOA release 2020-03-11

positive regulation of NIK/NF-kappaB signaling

1 reference

GOA release 2020-03-11

1 reference

based on heuristic

inferred from title

author name string

Ping Qiu

1

1 reference

7 March 2017

Michelle Kurpakus Wheater

2

1 reference

7 March 2017

Yue Qiu

3

1 reference

7 March 2017

Gabriel Sosne

4

1 reference

7 March 2017

language of work or name

0 references

publication date

1 June 2011

1 reference

7 March 2017

1 reference

7 March 2017

25

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7 March 2017

1815–1826

1 reference

7 March 2017

6

1 reference

7 March 2017

Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

16 March 2017

Thymosin beta 4 expression and nuclear transport are regulated by hMLH1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

16 March 2017

Integrating cell-signalling pathways with NF-kappaB and IKK function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

16 March 2017

Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

16 March 2017

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

16 March 2017

Actin-latrunculin A structure and function. Differential modulation of actin-binding protein function by latrunculin A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

16 March 2017

Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

16 March 2017

Actin, a central player in cell shape and movement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

7 April 2017

Regulation and function of NF-kappaB transcription factors in the immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

7 April 2017

Signalling pathways of the TNF superfamily: a double-edged sword

1 reference

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7 April 2017

Biological activities of thymosin beta4 defined by active sites in short peptide sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Exogenous thymosin beta4 prevents apoptosis in human intervertebral annulus cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Clinical review: Anti-TNFalpha therapies in uveitis: perspective on 5 years of clinical experience

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Antimicrobial and antistaphylococcal biofilm activity from the sea urchin Paracentrotus lividus

1 reference

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3 June 2018

Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration

1 reference

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3 June 2018

Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo

1 reference

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3 June 2018

Autoregulatory feedback loops terminating the NF-kappaB response

1 reference

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3 June 2018

Embryonic endothelial progenitor cell-mediated cardioprotection requires Thymosin beta4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions

1 reference

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3 June 2018

New regulators of NF-kappaB in inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells

1 reference

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3 June 2018

Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

RelA/NF-kappaB transcription factor associates with alpha-actinin-4.

1 reference

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3 June 2018

TNF-mediated inflammatory disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB.DNA interaction fold upon binding to NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Actin in transcription and transcription regulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Thymosin beta4 inhibits benzalkonium chloride-mediated apoptosis in corneal and conjunctival epithelial cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

ILK, PINCH and parvin: the tIPP of integrin signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Thymosin beta4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Overexpression of thymosin beta-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues

1 reference

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3 June 2018

Nuclear localisation of the G-actin sequestering peptide thymosin beta4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Thymosin-beta4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Role of thymosin beta4 in tumor metastasis and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

A phage display-based method for determination of relative affinities of mutants. Application of the actin-binding motifs in thymosin beta 4 and the villin headpiece

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Antimicrobial peptides from human platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Nuclear actin and actin-related proteins in chromatin remodeling.

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3 June 2018

Histone acetylation and recruitment of serum responsive factor and CREB-binding protein onto SM22 promoter during SM22 gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Nuclear matrix provides linkage sites for translocated NF-kappa B: morphological evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Dynamics of NF kappa B and Ikappa Balpha studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNa by fluorescence resonance energy transfer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

3 June 2018

Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Nucling interacts with nuclear factor-kappaB, regulating its cellular distribution.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Thymosin beta4 is cytoprotective in human gingival fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Actin cytoskeleton differentially modulates NF-kappaB-mediated IL-8 expression in myelomonocytic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Ku80 as a novel receptor for thymosin beta4 that mediates its intracellular activity different from G-actin sequestering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Thymosin beta 4 and its N-terminal tetrapeptide, AcSDKP, inhibit proliferation, and induce dysplastic, non-apoptotic nuclei and degranulation of mast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

The actin binding site on thymosin β4promotes angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Thymosin beta(4) reduces lethality and down-regulates inflammatory mediators in endotoxin-induced septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Endotoxin-Induced Endothelial Cell Proinflammatory Phenotypic Differentiation Requires Stress Fiber Polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101037

26 November 2018

Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biomedicine. Thymosins: clinical promise after a decades-long search

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective function of thymosin-beta and its derivative peptides on the programmed cell death of chick and rat neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of thymosin beta4 and protein in human wound fluid after abdominal surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HPLC-ESI-MS analysis of oral human fluids reveals that gingival crevicular fluid is the main source of oral thymosins β4and β10

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical characterization of thymosin beta 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of thymosin beta 4 in human blood cells and serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sulfoxide of thymosin beta 4 almost lacks the polymerization-inhibiting capacity for actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IkappaB-NF-kappaB structures: at the interface of inflammation control

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement

1 reference

https://pubmed.ncbi.nlm.nih.gov/21343177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1096/FJ.10-167940

1 reference

7 March 2017

0 references

1 reference

7 March 2017

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