NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING (Q28975619)

NLR family, CARD domain containing 3

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TANK-binding kinase 1

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Transmembrane protein 173

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13

Blossom Damania

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21 March 2017

Lu Zhang

1

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21 March 2017

Jinyao Mo

2

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21 March 2017

Karen V. Swanson

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21 March 2017

Haitao Wen

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21 March 2017

Alex Petrucelli

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Sean M. Gregory

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21 March 2017

Zhigang Zhang

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21 March 2017

Monika Schneider

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21 March 2017

Yan Jiang

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21 March 2017

Katherine A. Fitzgerald

10

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21 March 2017

Songying Ouyang

11

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21 March 2017

Zhi-Jie Liu

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21 March 2017

Hong-Bing Shu

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21 March 2017

Joseph A. Duncan

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21 March 2017

Jenny P.-Y. Ting

describes a project that uses

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21 March 2017

language of work or name

English

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publication date

20 March 2014

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40

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329–341

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ImageJ

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4011014/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

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Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway

23 March 2017

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The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

23 March 2017

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NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

23 March 2017

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NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice

23 March 2017

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Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

23 March 2017

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The structural basis for the sensing and binding of cyclic di-GMP by STING

23 March 2017

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Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

23 March 2017

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Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

23 March 2017

1 reference

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NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling

23 March 2017

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STING is a direct innate immune sensor of cyclic di-GMP

23 March 2017

1 reference

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The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

23 March 2017

1 reference

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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome

23 March 2017

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NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways

23 March 2017

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Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

23 March 2017

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A functional role for Nlrp6 in intestinal inflammation and tumorigenesis

23 March 2017

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IFI16 is an innate immune sensor for intracellular DNA

23 March 2017

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NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

23 March 2017

1 reference

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

23 March 2017

1 reference

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

23 March 2017

1 reference

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Activation of innate immune antiviral responses by Nod2

23 March 2017

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RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

23 March 2017

1 reference

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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

23 March 2017

1 reference

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The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

23 March 2017

1 reference

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

23 March 2017

1 reference

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Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver

23 March 2017

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NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

23 March 2017

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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

7 April 2017

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

7 April 2017

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Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

7 April 2017

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NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells

7 April 2017

1 reference

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STING manifests self DNA-dependent inflammatory disease

3 June 2018

1 reference

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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.

3 June 2018

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Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages

3 June 2018

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Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.

3 June 2018

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STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.

3 June 2018

1 reference

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Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

3 June 2018

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The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

NOD-like receptor (NLR) signaling beyond the inflammasome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

Innate instruction of adaptive immunity revisited: the inflammasome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

Recognition of viruses by innate immunity.

3 June 2018

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NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011014

10.1016/J.IMMUNI.2014.01.010

26 November 2018

Identifiers

DOI

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2911207

2911207

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1 reference

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