Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies (Q29398467)

Europe PubMed Central

title

Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies (English)

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14 April 2017

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D. Zádori

1

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14 April 2017

P. Klivényi

2

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14 April 2017

E. Vámos

3

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14 April 2017

F. Fülöp

4

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14 April 2017

J. Toldi

5

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14 April 2017

L. Vécsei

6

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14 April 2017

publication date

18 July 2009

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Journal of Neural Transmission

14 April 2017

published in

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14 April 2017

volume

116

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14 April 2017

issue

11

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14 April 2017

page(s)

1403-1409

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Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo

14 April 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS00702-009-0263-4

Kynurenine pathway abnormalities in Parkinson's disease.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS00702-009-0263-4

Biochemical abnormalities in Huntington's chorea brains

21 January 2018

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Crossref

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1-Methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats.

21 January 2018

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12 December 2020

Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases

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12 December 2020

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

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12 December 2020

Innervation of the substantia nigra

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12 December 2020

The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

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12 December 2020

Excitotoxic injury of the neostriatum: a model for Huntington's disease

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12 December 2020

3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims

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12 December 2020

Kynurenic acid has a dual action on AMPA receptor responses.

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12 December 2020

Quinolinic acid is a potent lipid peroxidant in rat brain homogenates

1 reference

12 December 2020

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor

1 reference

12 December 2020

The kynurenine pathway of tryptophan degradation as a drug target

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12 December 2020

Differential vulnerability of central neurons of the rat to quinolinic acid

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12 December 2020

The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine

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12 December 2020

Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes

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12 December 2020

An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.

1 reference

12 December 2020

A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists

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12 December 2020

3-Hydroxyanthranilic acid accumulation following administration of the 3-hydroxyanthranilic acid 3,4-dioxygenase inhibitor NCR-631

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12 December 2020

Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease

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12 December 2020

Kynurenine metabolism in Alzheimer's disease.

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12 December 2020

Quinolinate-induced cortical cholinergic damage: modulation by tryptophan metabolites.

1 reference

12 December 2020

Comparative behavioral and neurochemical studies with striatal kainic acid- or quinolinic acid-lesioned rats.

1 reference

12 December 2020

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

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12 December 2020

Brain Cytochrome Oxidase in Alzheimer's Disease

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12 December 2020

NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum.

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12 December 2020

Blood?Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism

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12 December 2020

Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid

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12 December 2020

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

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12 December 2020

Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family.

1 reference

12 December 2020

3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity.

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12 December 2020

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

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12 December 2020

In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum

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12 December 2020

Effect of 3-nitropropionic acid on kynurenine aminotransferase in the rat brain

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12 December 2020

3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum

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12 December 2020

Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors

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12 December 2020

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

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12 December 2020

Modulation of Quinolinic and Kynurenic Acid Content in the Rat Brain: Effects of Endotoxins and Nicotinylalanine

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12 December 2020

The thalamostriatal system: a highly specific network of the basal ganglia circuitry

1 reference

12 December 2020

Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: a potent inhibitor of 3-hydroxyanthranilic acid oxidase

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12 December 2020

Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl

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12 December 2020

Selective increase of NMDA-sensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease/Alzheimer's disease patients: an autoradiographic study

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12 December 2020

Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid

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12 December 2020

Presence of Kynurenine Hydroxylase in Developing Rat Brain

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12 December 2020

Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain

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12 December 2020

Direct evidence that release-stimulating alpha7* nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals

1 reference

12 December 2020

Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives

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12 December 2020

The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway

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12 December 2020

Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

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12 December 2020

The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.

1 reference

12 December 2020

Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis

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12 December 2020

Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid.

1 reference

12 December 2020

Expression of kynurenine aminotransferase in the subplate of the rat and its possible role in the regulation of programmed cell death

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12 December 2020

Two kynurenine aminotransferases in human brain

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12 December 2020

Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus

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12 December 2020

The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+.

1 reference

12 December 2020

Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate

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12 December 2020

Effect of 6-hydroxydopamine treatment on kynurenine aminotransferase-I (KAT-I) immunoreactivity of neurons and glial cells in the rat substantia nigra.

1 reference

12 December 2020

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

1 reference

12 December 2020

Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

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12 December 2020

Decreased expression of kynurenine aminotransferase-I (KAT-I) in the substantia nigra of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment

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12 December 2020

Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection

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12 December 2020

Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro

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12 December 2020

On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo

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12 December 2020

Metabolism of [5‐3H]Kynurenine in the Rat Brain In Vivo: Evidence for the Existence of a Functional Kynurenine Pathway

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12 December 2020

Biochemical evidence for glutamate as neurotransmitter in corticostriatal and corticothalamic fibres in rat brain

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12 December 2020

Excitatory amino acids and Alzheimer's disease

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12 December 2020

Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease

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12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration

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12 December 2020

Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus

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12 December 2020

Effects of in vivo sodium azide administration on the immunohistochemical localization of kynurenine aminotransferase in the rat brain

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12 December 2020

Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease

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12 December 2020

The Janus-face kynurenic acid

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12 December 2020

10.1007/S00702-009-0263-4

Identifiers

DOI

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