BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling (Q30168274)

9 June 2017

title

BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling (English)

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9 June 2017

S H Lee

1

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9 June 2017

M Eom

2

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9 June 2017

S J Lee

3

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9 June 2017

S Kim

4

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9 June 2017

H J Park

5

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9 June 2017

D Park

6

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9 June 2017

language of work or name

English

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publication date

17 April 2001

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Journal of Biological Chemistry

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published in

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volume

276

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9 June 2017

issue

27

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9 June 2017

page(s)

25066-25072

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Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

9 June 2017

cites work

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Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

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The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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A novel regulator of p21-activated kinases

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Molecular cloning of neuronally expressed mouse betaPix isoforms

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alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms

21 January 2018

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Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

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A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins

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alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

21 January 2018

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

21 January 2018

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Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

21 January 2018

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Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

21 January 2018

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Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.

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SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis

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A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

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The p38 signal transduction pathway: activation and function

21 January 2018

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PAK promotes morphological changes by acting upstream of Rac.

21 January 2018

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Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization

21 January 2018

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

21 January 2018

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Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

21 January 2018

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Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

21 January 2018

1 reference

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Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

21 January 2018

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MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M010892200

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9 June 2017

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