Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease (Q30251565)

13 June 2017

Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease (English)

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metabolic dysfunction–associated steatotic liver disease

13 June 2017

0 references

1 reference

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non-alcoholic fatty liver

inferred from title

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27091156%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Xavier Verhelst

3

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4 June 2020

Lindsey Devisscher

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27091156%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Anja Geerts

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27091156%20AND%20SRC:MED&resulttype=core&format=json

Christophe Van Steenkiste

4 June 2020

2

object named as

Christophe Van Steenkiste

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27091156%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

4

Hans Van Vlierberghe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27091156%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

publication date

18 April 2016

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Cellular and Molecular Life Sciences

13 June 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27091156%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

73

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27091156%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

18

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4 June 2020

page(s)

3419-3431

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https://scigraph.springernature.com/pub.10.1007/s00018-016-2222-1

4 June 2020

exact match

0 references

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21 January 2018

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Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice

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Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response

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Obesity decreases perioperative tissue oxygenation

21 January 2018

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Metabolic signatures of human adipose tissue hypoxia in obesity

21 January 2018

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Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation

21 January 2018

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Brown adipose tissue as an anti-obesity tissue in humans

21 January 2018

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Vascular rarefaction mediates whitening of brown fat in obesity.

21 January 2018

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The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

21 January 2018

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Type 2 diabetes as a disease of ectopic fat?

21 January 2018

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Oxygen: modulator of metabolic zonation and disease of the liver

21 January 2018

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High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo

21 January 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

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21 January 2018

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Novel roles of hypoxia response system in glucose metabolism and obesity

21 January 2018

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Molecular basis of the VHL hereditary cancer syndrome

21 January 2018

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Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

21 January 2018

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HIF-1 versus HIF-2--is one more important than the other?

21 January 2018

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Regulation of angiogenesis by oxygen and metabolism.

21 January 2018

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Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

21 January 2018

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

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Adipose tissue angiogenesis: impact on obesity and type-2 diabetes

21 January 2018

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Angiogenesis and development of adipose tissue

21 January 2018

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Hypoxia and adipose tissue function and dysfunction in obesity.

21 January 2018

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Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity

21 January 2018

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Mitochondrial uncoupling proteins and energy metabolism

21 January 2018

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Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.

21 January 2018

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Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

21 January 2018

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

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Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

21 January 2018

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Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice

21 January 2018

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Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction.

21 January 2018

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EPAS1 promotes adipose differentiation in 3T3-L1 cells

21 January 2018

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Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation

21 January 2018

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Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients

21 January 2018

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21 January 2018

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Prolyl hydroxylase domain protein 2 plays a critical role in diet-induced obesity and glucose intolerance

21 January 2018

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Chronic hypoxia: common traits between chronic obstructive pulmonary disease and altitude

21 January 2018

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Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.

21 January 2018

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A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo

21 January 2018

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

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Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes

21 January 2018

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Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia

21 January 2018

1 reference

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

21 January 2018

1 reference

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Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective

21 January 2018

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Dichotomous effects of VEGF-A on adipose tissue dysfunction.

21 January 2018

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Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis

21 January 2018

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Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance.

21 January 2018

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Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice

21 January 2018

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Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue

21 January 2018

1 reference

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The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue.

21 January 2018

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Modest hypoxia significantly reduces triglyceride content and lipid droplet size in 3T3-L1 adipocytes

21 January 2018

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Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis

21 January 2018

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Pathogenesis of non-alcoholic fatty liver disease.

21 January 2018

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21 January 2018

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Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity

21 January 2018

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Association of obstructive sleep apnoea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis

21 January 2018

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Intermittent hypoxia exacerbates metabolic effects of diet-induced obesity

21 January 2018

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Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha

21 January 2018

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Hypoxia-inducible factors and their roles in energy metabolism

21 January 2018

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Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis

21 January 2018

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Hypoxia-inducible factor 2 regulates hepatic lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

21 January 2018

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Roles of PPARs in NAFLD: potential therapeutic targets

21 January 2018

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

21 January 2018

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New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease

21 January 2018

1 reference

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Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Zonation of glucose and fatty acid metabolism in the liver: mechanism and metabolic consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

21 January 2018

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Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α.

21 January 2018

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Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones

21 January 2018

1 reference

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Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-016-2222-1

Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice

21 January 2018

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Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.

21 January 2018

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From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery.

21 January 2018

1 reference

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Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane

21 January 2018

1 reference

12 December 2020

HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice

1 reference

12 December 2020

Acute alcohol produces hypoxia directly in rat liver tissue in vivo: role of Kupffer cells

1 reference

12 December 2020

Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.

1 reference

12 December 2020

HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction

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12 December 2020

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

1 reference

12 December 2020

HIF-1α is a major and complex player in alcohol induced liver diseases

1 reference

12 December 2020

Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes

1 reference

12 December 2020

Modulation of adipokine production, glucose uptake and lactate release in human adipocytes by small changes in oxygen tension

1 reference

12 December 2020

Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma.

1 reference

12 December 2020

Oxygen deprivation and the cellular response to hypoxia in adipocytes - perspectives on white and brown adipose tissues in obesity

1 reference

12 December 2020

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

1 reference

12 December 2020

Hypoxia Converts Human Macrophages Into Triglyceride-Loaded Foam Cells

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12 December 2020

Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo

1 reference

12 December 2020

Macrophage HIF-2α ameliorates adipose tissue inflammation and insulin resistance in obesity

1 reference

12 December 2020

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1 reference

12 December 2020

10.1007/S00018-016-2222-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27091156%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference