A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. (Q30372203)

29 September 2017

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. (English)

1 reference

29 September 2017

Matthew D Cheeseman

5

0 references

Alan M Jones

object named as

Alan M Jones

1

0 references

Paul Workman

17

object named as

Paul Workman

1 reference

29 September 2017

Isaac M Westwood

2

1 reference

29 September 2017

James D Osborne

3

1 reference

29 September 2017

Thomas P Matthews

4

1 reference

29 September 2017

Martin G Rowlands

6

1 reference

29 September 2017

Fiona Jeganathan

7

1 reference

29 September 2017

Rosemary Burke

8

1 reference

29 September 2017

Diane Lee

9

1 reference

29 September 2017

Nadia Kadi

10

1 reference

29 September 2017

Manjuan Liu

11

1 reference

29 September 2017

Meirion Richards

12

1 reference

29 September 2017

Craig McAndrew

13

1 reference

29 September 2017

Norhakim Yahya

14

1 reference

29 September 2017

Sarah E Dobson

15

1 reference

29 September 2017

Keith Jones

16

1 reference

29 September 2017

Ian Collins

18

1 reference

29 September 2017

Rob L M van Montfort

19

1 reference

29 September 2017

language of work or name

English

0 references

publication date

6 October 2016

1 reference

29 September 2017

1 reference

29 September 2017

6

1 reference

29 September 2017

34701

1 reference

Creative Commons Attribution 4.0 International

29 September 2017

start time

6 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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4 June 2018

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The novolactone natural product disrupts the allosteric regulation of Hsp70

4 June 2018

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Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

4 June 2018

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Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket

4 June 2018

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Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.

4 June 2018

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Functional analysis of Hsp70 inhibitors

4 June 2018

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Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein

4 June 2018

1 reference

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Hsp70 chaperone dynamics and molecular mechanism

4 June 2018

1 reference

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Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity

4 June 2018

1 reference

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Overview of the CCP4 suite and current developments

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance

4 June 2018

1 reference

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Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

4 June 2018

1 reference

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Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?

4 June 2018

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Heat shock protein 70 (hsp70) as an emerging drug target.

4 June 2018

1 reference

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The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange

4 June 2018

1 reference

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Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

PHENIX: a comprehensive Python-based system for macromolecular structure solution

4 June 2018

1 reference

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4 June 2018

1 reference

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Pharmacological targeting of the Hsp70 chaperone

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

A small molecule inhibitor of inducible heat shock protein 70.

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Phasercrystallographic software

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Scaling and assessment of data quality

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

4 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Using a xenograft model of human breast cancer metastasis to find genes associated with clinically aggressive disease

4 June 2018

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Coot: model-building tools for molecular graphics

4 June 2018

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Retrieval of crystallographically-derived molecular geometry information.

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Ligand efficiency: a useful metric for lead selection

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

The CCP4 molecular-graphics project

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

S-adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5052559

Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells.

4 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSREP34701

ATPases as drug targets: insights from heat shock proteins 70 and 90.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSREP34701

Selectivity of the molecular chaperone-specific immunosuppressive agent 15-deoxyspergualin: modulation of Hsc70 ATPase activity without compromising DnaJ chaperone interactions

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27708405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP34701

1 reference

Dimensions Publication ID

29 September 2017

0 references

1 reference

29 September 2017

PubMed publication ID

27708405

1 reference