TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy (Q30399437)

21 June 2017

title

TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy (English)

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3

Mark J Smyth

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4

Ana C Anderson

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William C Dougall

1

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21 June 2017

Sema Kurtulus

series ordinal

2

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21 June 2017

publication date

1 March 2017

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21 June 2017

published in

Immunological Reviews

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21 June 2017

volume

276

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issue

1

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21 June 2017

page(s)

112-120

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Immune modulation in cancer with antibodies

21 June 2017

cites work

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The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

21 January 2018

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Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR.

21 January 2018

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A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

21 January 2018

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Vstm3 is a member of the CD28 family and an important modulator of T-cell function

21 January 2018

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The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

21 January 2018

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T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling

21 January 2018

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Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells

21 January 2018

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CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains

21 January 2018

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Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.

21 January 2018

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Cutting edge: TIGIT has T cell-intrinsic inhibitory functions

21 January 2018

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Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice

21 January 2018

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The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

21 January 2018

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Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)

21 January 2018

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The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1.

21 January 2018

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Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection.

21 January 2018

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CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia

21 January 2018

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Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

21 January 2018

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TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients

21 January 2018

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Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity

21 January 2018

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Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome

21 January 2018

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Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering

21 January 2018

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The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function

21 January 2018

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Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2.

21 January 2018

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Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

21 January 2018

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Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

21 January 2018

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TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.

21 January 2018

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The TIGIT/CD226 axis regulates human T cell function

21 January 2018

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Melanoma Cells Control Antimelanoma CTL Responses via Interaction between TIGIT and CD155 in the Effector Phase

21 January 2018

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TIGIT predominantly regulates the immune response via regulatory T cells.

21 January 2018

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T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis

21 January 2018

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TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals

21 January 2018

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Adaptive NK Cells with Low TIGIT Expression Are Inherently Resistant to Myeloid-Derived Suppressor Cells

21 January 2018

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DNAX Accessory Molecule-1 Mediated Recognition of Freshly Isolated Ovarian Carcinoma by Resting Natural Killer Cells

21 January 2018

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The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells

21 January 2018

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DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vgamma9Vdelta2 T cells

21 January 2018

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Identification of endothelial cell junctional proteins and lymphocyte receptors involved in transendothelial migration of human effector memory CD4+ T cells

21 January 2018

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T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8+ T-Cell Exhaustion and Poor Clinical Outcome in AML Patients.

21 January 2018

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Balancing natural killer cell activation through paired receptors

21 January 2018

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DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors

21 January 2018

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DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases

21 January 2018

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Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy

21 January 2018

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Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells

21 January 2018

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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

21 January 2018

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Regulatory T cells in cancer immunotherapy

21 January 2018

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Th17 cells are long lived and retain a stem cell-like molecular signature

21 January 2018

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T helper 17 cells promote cytotoxic T cell activation in tumor immunity

21 January 2018

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Cancer-Associated Myeloid Regulatory Cells

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Accelerated tumor growth in mice deficient in DNAM-1 receptor

21 January 2018

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Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice

21 January 2018

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Identification of CD112R as a novel checkpoint for human T cells

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Identifiers

DOI

10.1111/IMR.12518

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21 June 2017

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