The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis (Q30437640)

19 August 2017

The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis (English)

1 reference

19 August 2017

1 reference

Luke Martin McCaffrey

series ordinal

1

1 reference

PMCID

2701573

19 August 2017

Ian G Macara

series ordinal

2

1 reference

19 August 2017

1 June 2009

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19 August 2017

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19 August 2017

23

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19 August 2017

12

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19 August 2017

1450-1460

1 reference

PMCID

2701573

describes a project that uses

19 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2701573/fullTextXML

inferred from PubMed Central ID database lookup

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Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization

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Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.

20 June 2018

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Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells

20 June 2018

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Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways

20 June 2018

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Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex

20 June 2018

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The PAR proteins: fundamental players in animal cell polarization

20 June 2018

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The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity

20 June 2018

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Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity

20 June 2018

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Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.

20 June 2018

1 reference

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The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium

20 June 2018

1 reference

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Evidence for a stem cell hierarchy in the adult human breast

20 June 2018

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BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

20 June 2018

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p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres

20 June 2018

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PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.

20 June 2018

1 reference

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Generation of a functional mammary gland from a single stem cell

20 June 2018

1 reference

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Purification and unique properties of mammary epithelial stem cells

20 June 2018

1 reference

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Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

20 June 2018

1 reference

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Key stages in mammary gland development: the mammary end bud as a motile organ.

20 June 2018

1 reference

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The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex

20 June 2018

1 reference

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Modelling glandular epithelial cancers in three-dimensional cultures

20 June 2018

1 reference

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The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila

20 June 2018

1 reference

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20 June 2018

On mammary stem cells

1 reference

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aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

20 June 2018

1 reference

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Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

20 June 2018

1 reference

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In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

20 June 2018

1 reference

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Epithelial polarity and tubulogenesis in vitro.

20 June 2018

1 reference

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Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Identification of Stem Cell Units in the Terminal End Bud and Duct of the Mouse Mammary Gland

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Mammary ductal elongation: differentiation of myoepithelium and basal lamina during branching morphogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Phosphorylation-dependent binding of 14-3-3 to the polarity protein Par3 regulates cell polarity in mammalian epithelia.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2701573

Reconstruction of human mammary tissues in a mouse model

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19528321

12 December 2020

inferred from PubMed ID database lookup

Columnar cell lesions of the breast

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19528321

12 December 2020

inferred from PubMed ID database lookup

Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19528321

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1101/GAD.1795909

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

PMCID

2701573