Diversity of actions of GnRHs mediated by ligand-induced selective signaling (Q30439870)

18 August 2017

1 reference

title

Diversity of actions of GnRHs mediated by ligand-induced selective signaling (English)

1 reference

18 August 2017

Zhi-Liang Lu

5

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Adam J Pawson

object named as

Adam J Pawson

2

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Robert P. Millar

object named as

Robert P Millar

1

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author name string

Kevin Morgan

3

1 reference

PMCID

2667102

18 August 2017

Emilie F Rissman

4

1 reference

18 August 2017

23 August 2007

1 reference

Frontiers in Neuroendocrinology

18 August 2017

1 reference

18 August 2017

29

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18 August 2017

1

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18 August 2017

17-35

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Signaling complexes associated with the type I gonadotropin-releasing hormone (GnRH) receptor: colocalization of extracellularly regulated kinase 2 and GnRH receptor within membrane rafts

18 August 2017

1 reference

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Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

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1 reference

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20 June 2018

1 reference

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Programming of GnRH feedback controls timing puberty and adult reproductive activity

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1 reference

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1 reference

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1 reference

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Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion

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1 reference

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Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges

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1 reference

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Evidence that the type-2 gonadotrophin-releasing hormone (GnRH) receptor mediates the behavioural effects of GnRH-II on feeding and reproduction in musk shrews.

20 June 2018

1 reference

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1 reference

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Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.

20 June 2018

1 reference

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1 reference

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Extracellular signal-regulated protein kinase, but not c-Jun N-terminal kinase, is activated by type II gonadotropin-releasing hormone involved in the inhibition of ovarian cancer cell proliferation.

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1 reference

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1 reference

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Evolution of GnRH ligand precursors and GnRH receptors in protochordate and vertebrate species

20 June 2018

1 reference

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Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor

20 June 2018

1 reference

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Emerging functions of gonadotropin-releasing hormone II in mammalian physiology and behaviour

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1 reference

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Bi-directional associations between galanin and luteinizing hormone-releasing hormone neuronal systems in the human diencephalon

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1 reference

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Antiproliferative effects of the GnRH antagonist cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I receptor

20 June 2018

1 reference

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20 June 2018

1 reference

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Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua

20 June 2018

1 reference

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The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans

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1 reference

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1 reference

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20 June 2018

1 reference

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GnRH antagonists in the treatment of gynecological and breast cancers

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1 reference

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20 June 2018

1 reference

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A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12

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1 reference

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1 reference

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1 reference

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The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs

20 June 2018

1 reference

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Differential desensitization and internalization of three different bullfrog gonadotropin-releasing hormone receptors.

20 June 2018

1 reference

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20 June 2018

1 reference

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Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors.

20 June 2018

1 reference

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Molecular identification of the insect adipokinetic hormone receptors

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1 reference

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Impact of aromatic residues within transmembrane helix 6 of the human gonadotropin-releasing hormone receptor upon agonist and antagonist binding

20 June 2018

1 reference

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1 reference

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1 reference

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1 reference

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20 June 2018

1 reference

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1 reference

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Three distinct types of GnRH receptor characterized in the bullfrog.

20 June 2018

1 reference

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20 June 2018

1 reference

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Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor

20 June 2018

1 reference

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Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line.

20 June 2018

1 reference

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20 June 2018

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The tail of the gonadotrophin-releasing hormone receptor: desensitization at, and distal to, G protein-coupled receptors.

20 June 2018

1 reference

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Characterization of an intrinsically fluorescent gonadotropin-releasing hormone receptor and effects of ligand binding on receptor lateral diffusion

20 June 2018

1 reference

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Agonist-induced endocytosis and recycling of the gonadotropin-releasing hormone receptor: effect of beta-arrestin on internalization kinetics

20 June 2018

1 reference

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Sex differences in mammalian and chicken-II gonadotropin-releasing hormone immunoreactivity in musk shrew brain

20 June 2018

1 reference

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Molecular cloning, genomic organization and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to gonadotropin-releasing hormone receptors for vertebrates.

20 June 2018

1 reference

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Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.

20 June 2018

1 reference

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Mechanism of GnRH receptor signaling: combinatorial cross-talk of Ca2+ and protein kinase C.

20 June 2018

1 reference

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Advances in understanding gonadotrophin-releasing hormone receptor structure and ligand interactions.

20 June 2018

1 reference

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Central administration of chicken gonadotropin-releasing hormone-II enhances courtship behavior in a female sparrow.

20 June 2018

1 reference

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Chicken GnRH II-like peptides and a GnRH receptor selective for chicken GnRH II in amphibian sympathetic ganglia.

20 June 2018

1 reference

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Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor

20 June 2018

1 reference

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Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines

20 June 2018

1 reference

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Origin of mammalian gonadotropin-releasing hormones

20 June 2018

1 reference

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GnRH analogues for contraception

20 June 2018

1 reference

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Gonadotropin-releasing hormone and its analogs

20 June 2018

1 reference

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Absence of rapid desensitization of the mouse gonadotropin-releasing hormone receptor

20 June 2018

1 reference

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Expression and signal transduction pathways of gonadotropin-releasing hormone receptors

20 June 2018

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Gonadotrophin-releasing hormone agonists. A guide to use and selection

20 June 2018

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Structure of chicken hypothalamic luteinizing hormone-releasing hormone. I. Structural determination on partially purified material.

20 June 2018

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Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses

20 June 2018

1 reference

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Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence

20 June 2018

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Isolation and properties of the FSH and LH-releasing hormone.

20 June 2018

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Gonadotrophin-releasing hormone--diversity of functions and clinical applications

20 June 2018

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The mammalian GnRH gene and its pivotal role in reproduction

20 June 2018

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Molecular conformation of gonadoliberin using two-dimensional NMR spectroscopy

20 June 2018

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Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis

20 June 2018

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Modulation of M current in frog sympathetic ganglion cells

20 June 2018

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Gonadotropin-releasing hormone gene expression in MDA-MB-231 and ZR-75-1 breast carcinoma cell lines

20 June 2018

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Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice

20 June 2018

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Clinical uses of gonadotropin-releasing hormone analogues

20 June 2018

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Gonadotropin-releasing hormone and its analogues

20 June 2018

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Clinical applications of gonadotropin-releasing hormones in reproductive disorders

20 June 2018

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Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor

20 June 2018

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Direct effects of luteinizing hormone-releasing hormone agonists and antagonists on MCF-7 mammary cancer cells

20 June 2018

1 reference

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Role of gonadotrophin releasing hormones in the reproductive behaviour of female ring doves (Streptopelia risoria)

20 June 2018

1 reference

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Heterogeneity of Vertebrate Luteinizing Hormone-Releasing Hormone

20 June 2018

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Higher molecular weight immunoreactive species of luteinizing hormone releasing hormone: possible precursors of the hormone

20 June 2018

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Actions of Hypothalamic-Hypophysiotropic Hormones on the Brain

20 June 2018

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Structural features of luliberin (luteinising hormone-releasing factor) inferred from fluorescence measurements

20 June 2018

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Neural control of the pituitary gland.

20 June 2018

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Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor.

26 November 2018

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Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptor

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Gonadotropin-releasing hormone II stimulates female sexual behavior in marmoset monkeys

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Molecular cloning of a molluscan gonadotropin-releasing hormone receptor orthologue specifically expressed in the gonad.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: evidence for ligand-selective, receptor-active conformations.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Antagonist and agonist binding models of the human gonadotropin-releasing hormone receptor

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Outside-In and Inside-Out Signaling: The New Concept that Selectivity of Ligand Binding at the Gonadotropin-Releasing Hormone Receptor Is Modulated by the Intracellular Environment

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for beta-arrestin-independent internalization

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

The promoter of the rat gonadotropin-releasing hormone receptor gene directs the expression of the human placental alkaline phosphatase reporter gene in gonadotrope cells in the anterior pituitary gland as well as in multiple extrapituitary tissues.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Multiple determinants for rapid agonist-induced internalization of a nonmammalian gonadotropin-releasing hormone receptor: a putative palmitoylation site and threonine doublet within the carboxyl-terminal tail Are critical

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Six novel gonadotropin-releasing hormones are encoded as triplets on each of two genes in the protochordate, Ciona intestinalis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Spatio-temporal expression of gonadotropin-releasing hormone receptor subtypes in gonadotropes, somatotropes and lactotropes in the cichlid fish.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: a role for POU homeodomain transcription factors.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Gonadotropin-releasing hormone receptor expression in the human prostate

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Binding of Agonist but Not Antagonist Leads to Fluorescence Resonance Energy Transfer between Intrinsically Fluorescent Gonadotropin-Releasing Hormone Receptors

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

A developmental increase in the expression of messenger ribonucleic acid encoding a second form of gonadotropin-releasing hormone in the rhesus macaque hypothalamus.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Gonadotropin-releasing hormone receptor mRNA expression in the ovaries of neonatal and adult rats.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Promoter transgenics reveal multiple gonadotropin-releasing hormone-I-expressing cell populations of different embryological origin in mouse brain.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Contrasting internalization kinetics of human and chicken gonadotropin-releasing hormone receptors mediated by C-terminal tail

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: localization of attachment site to Cys residue in N-terminal segment

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptors

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Two populations of luteinizing hormone-releasing hormone neurons in the forebrain of the rhesus macaque during embryonic development

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Structure of chicken hypothalamic luteinizing hormone-releasing hormone. II. Isolation and characterization.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667102

Luteinizing hormone-releasing hormone and thyrotropin-releasing hormone induction of female sexual receptivity in the lizard, Anolis carolinensis

26 November 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Clinical applications of GnRH and its analogues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Pivotal role for the cytoplasmic carboxyl-terminal tail of a nonmammalian gonadotropin-releasing hormone receptor in cell surface expression, ligand binding, and receptor phosphorylation and internalization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Rat granulosa cells express the gonadotrophin-releasing hormone gene: evidence from in-situ hybridization histochemistry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Gonadotropin-releasing hormone binding sites in human breast carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Gonadotropin-Releasing Hormone (GnRH)-Binding Sites in Human Breast Cancer Cell Lines and Inhibitory Effects of GnRH Antagonists*

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

The use of luteinizing hormone releasing hormone agonists and antagonists in gynaecological cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Peptidergic transmitters in synaptic boutons of sympathetic ganglia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Chicken II luteinizing hormone-releasing hormone inhibits the M-current of bullfrog sympathetic neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Comparative Aspects of Luteinizing Hormone-Releasing Hormone Structure and Function in Vertebrate Phylogeny*

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Two molecular forms of gonadotropin-releasing hormone (GnRH-I and GnRH-II) are expressed by two separate populations of cells in the rhesus macaque hypothalamus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

The Luteinizing Hormone-Releasing Hormone Receptor in Human Prostate Cancer Cells: Messenger Ribonucleic Acid Expression, Molecular Size, and Signal Transduction Pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Comparative structure-activity studies on mammalian [Arg8] LH-RH and chicken [Gln8] LH-RH by fluorimetric titration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Stimulating male sexual behavior with repetitive pulses of GnRH in female green iguanas,Iguana iguana

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Actions of two forms of gonadotropin releasing hormone and a GnRH antagonist on spawning behavior of the goldfish Carassius auratus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2007.06.002

Two forms of gonadotropin-releasing hormone (GnRH) are expressed in human breast tissue and overexpressed in breast cancer: a putative mechanism for the antiproliferative effect of GnRH by down-regulation of acidic ribosomal phosphoproteins P1 and P

7 January 2021

1 reference

12 December 2020

Gonadotropin-releasing hormone I analog acts as an antiapoptotic factor in mouse blastocysts

1 reference

12 December 2020

A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor

1 reference

12 December 2020

Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors

1 reference

12 December 2020

Human oviductal gonadotropin-releasing hormone: possible implications in fertilization, early embryonic development, and implantation

1 reference

12 December 2020

10.1016/J.YFRNE.2007.06.002

Identifiers

DOI

1 reference

18 August 2017

1 reference

18 August 2017

1 reference

PMCID

2667102