Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells (Q30449939)

12 August 2017

Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells (English)

1 reference

12 August 2017

Lihong Wang

1

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12 August 2017

Cresson D Fraley

2

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12 August 2017

Jesika Faridi

3

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12 August 2017

Arthur Kornberg

4

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12 August 2017

Richard A Roth

5

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12 August 2017

language of work or name

English

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publication date

11 September 2003

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Proceedings of the National Academy of Sciences of the United States of America

12 August 2017

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12 August 2017

100

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12 August 2017

20

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12 August 2017

11249-11254

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describes a project that uses

12 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC208743/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Tor signalling in bugs, brain and brawn

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Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

20 June 2018

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Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

20 June 2018

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

20 June 2018

1 reference

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Synapsis of DNA ends by DNA-dependent protein kinase

20 June 2018

1 reference

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Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

20 June 2018

1 reference

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

20 June 2018

1 reference

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Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

20 June 2018

1 reference

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Mammalian TOR: a homeostatic ATP sensor

20 June 2018

1 reference

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Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity

20 June 2018

1 reference

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

20 June 2018

1 reference

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

20 June 2018

1 reference

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Role of inorganic polyphosphate in promoting ribosomal protein degradation by the Lon protease in E. coli

20 June 2018

1 reference

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

20 June 2018

1 reference

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A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Inorganic polyphosphate: a molecule of many functions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Novel assay reveals multiple pathways regulating stress-induced accumulations of inorganic polyphosphate in Escherichia coli.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

A soluble exopolyphosphatase of Saccharomyces cerevisiae. Purification and characterization

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

The gene for a major exopolyphosphatase of Saccharomyces cerevisiae

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=208743

Inorganic polyphosphate in mammalian cells and tissues

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1534805100

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1534805100

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1534805100

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1534805100

21 January 2018

Identifiers

DOI

10.1073/PNAS.1534805100

1 reference

12 August 2017

0 references

1 reference

12 August 2017

1 reference