Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function (Q30468589)

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English	Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function	scientific article

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18 January 2020

Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function (English)

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18 January 2020

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based on heuristic

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sensorineural hearing loss

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based on heuristic

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Agueda Gonzalez-rodriguez

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18 January 2020

Isabel Varela-Nieto

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18 January 2020

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Silvia Murillo-Cuesta

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18 January 2020

Guadalupe Camarero

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18 January 2020

Lourdes Rodríguez De La Rosa

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18 January 2020

Deborah J Burks

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18 January 2020

Carlos Avendaño

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18 January 2020

Angela M Valverde

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18 January 2020

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30 March 2012

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18 January 2020

Molecular Medicine

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18 January 2020

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18 January 2020

260-269

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18 January 2020

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Creative Commons Attribution 4.0 International

1 December 2011

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The role of insulin-like growth factor-I in the physiopathology of hearing.

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RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development

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Differential sensitivity to adrenergic stimulation underlies the sexual dimorphism in the development of diabetes caused by Irs-2 deficiency

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A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice

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RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.

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Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice

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Diabetes-related changes in hearing

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14 July 2018

Early sensorineural hearing loss in ob/ob mouse, an animal model of type 2 diabetes

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14 July 2018

Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis.

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Insulin-like growth factors and the brain

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Diabetes and hearing impairment in the United States: audiometric evidence from the National Health and Nutrition Examination Survey, 1999 to 2004

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A network of growth and transcription factors controls neuronal differentation and survival in the developing ear.

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14 July 2018

Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination

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14 July 2018

Regulating insulin signaling and beta-cell function through IRS proteins

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14 July 2018

Molecular and physiological bases of the K+ circulation in the mammalian inner ear.

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14 July 2018

Effects of type 2 diabetes mellitus on cochlear structure in humans

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14 July 2018

Critical nodes in signalling pathways: insights into insulin action

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14 July 2018

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

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14 July 2018

Characterization of hearing loss in aged type II diabetics

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14 July 2018

Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation

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14 July 2018

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

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14 July 2018

The effect of diabetes on sensorineural hearing loss

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14 July 2018

Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice

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14 July 2018

Mutant mouse models of insulin-like growth factor actions in the central nervous system

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14 July 2018

IRS proteins and the common path to diabetes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3324951

14 July 2018

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

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14 July 2018

Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells

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New approximations for the variance in cavalieri sampling

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14 July 2018

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

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14 July 2018

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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14 July 2018

Disruption of IRS-2 causes type 2 diabetes in mice

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14 July 2018

An ATP-dependent inwardly rectifying potassium channel, KAB-2 (Kir4. 1), in cochlear stria vascularis of inner ear: its specific subcellular localization and correlation with the formation of endocochlear potential.

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Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene

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14 July 2018

Protein tyrosine phosphatase 1B interacts with the activated insulin receptor

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14 July 2018

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

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Some new, simple and efficient stereological methods and their use in pathological research and diagnosis.

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Age-related functional and structural retinal modifications in the Igf1-/- null mouse.

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Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice

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Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit.

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Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3324951

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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26 November 2018

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

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31 March 2020

Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00328

31 March 2020

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10.2119/MOLMED.2011.00328

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Europe PubMed Central

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18 January 2020

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9 September 2019

https://scigraph.springernature.com/pub.10.2119/molmed.2011.00328

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18 January 2020

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18 January 2020

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