Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation (Q28156047)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740672&resulttype=core&format=json

Insulin-like growth factor I receptor

12 May 2020

main subject

brain

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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

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Brain derived neurotrophic factor

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Insulin-like growth factor 1

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Insulin receptor substrate 2

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Pancreatic and duodenal homeobox 1

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12

Morris F White

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author name string

Markus Schubert

1

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12 May 2020

Derek P Brazil

2

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12 May 2020

Deborah J Burks

3

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12 May 2020

Jake A Kushner

4

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12 May 2020

Jing Ye

5

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12 May 2020

Carrie L Flint

6

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12 May 2020

Janet Farhang-Fallah

7

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12 May 2020

Pieter Dikkes

8

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12 May 2020

Xavier M Warot

9

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12 May 2020

Carlos Rio

10

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12 May 2020

Gabriel Corfas

11

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12 May 2020

Morris F White

12

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12 May 2020

language of work or name

English

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publication date

6 August 2003

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published in

Journal of Neuroscience

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12 May 2020

volume

23

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issue

18

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12 May 2020

page(s)

7084-7092

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

12 May 2020

cites work

1 reference

12 December 2020

Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene

1 reference

12 December 2020

Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes

1 reference

12 December 2020

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

12 December 2020

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

1 reference

12 December 2020

Increased insulin-like growth factor-I (IGF-I) expression during early postnatal development differentially increases neuron number and growth in medullary nuclei of the mouse

1 reference

12 December 2020

Insulin-like growth factor-I and central nervous system development

1 reference

12 December 2020

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies

1 reference

12 December 2020

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

1 reference

12 December 2020

IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis

1 reference

12 December 2020

Diabetes and dementia: is the brain another site of end-organ damage?

1 reference

12 December 2020

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

1 reference

12 December 2020

A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease.

1 reference

12 December 2020

Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters

1 reference

12 December 2020

Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus.

1 reference

12 December 2020

Neural tube defects and the 13q deletion syndrome: evidence for a critical region in 13q33-34.

1 reference

12 December 2020

Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels.

1 reference

12 December 2020

Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway

1 reference

12 December 2020

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

1 reference

12 December 2020

IRS-2 pathways integrate female reproduction and energy homeostasis

1 reference

12 December 2020

Regenerating the damaged central nervous system

1 reference

12 December 2020

Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.

1 reference

12 December 2020

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

1 reference

12 December 2020

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

12 December 2020

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

1 reference

12 December 2020

Complex trait analysis of the hippocampus: mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice.

1 reference

12 December 2020

Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture.

1 reference

12 December 2020

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

12 December 2020

Pdx1 restores beta cell function in Irs2 knockout mice

1 reference

12 December 2020

RhoGAP: the next big thing for small mice?

1 reference

12 December 2020

Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development

1 reference

12 December 2020

The GSK3 beta signaling cascade and neurodegenerative disease.

1 reference

12 December 2020

Does insulin dysfunction play a role in Alzheimer's disease?

1 reference

12 December 2020

The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Regulation of cerebral cortical size by control of cell cycle exit in neural precursors

1 reference

12 December 2020

Deciphering the genetic basis of Alzheimer's disease

1 reference

12 December 2020

IRS proteins and the common path to diabetes

1 reference

12 December 2020

Functions of PI 3-kinase in development of the nervous system

1 reference

12 December 2020

Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.

1 reference

12 December 2020

Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.

1 reference

12 December 2020

The role of the metabolic lesion in Alzheimer's disease.

1 reference

12 December 2020

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

1 reference

12 December 2020

Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans.

1 reference

12 December 2020

Muscarinic potentiation of GABA(A) receptor currents is gated by insulin signaling in the prefrontal cortex.

1 reference

12 December 2020

Expression and function of IRS-1 in insulin signal transmission.

1 reference

12 December 2020

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

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12 December 2020

Insulin receptors mediate growth effects in cultured fetal neurons. I. Rapid stimulation of protein synthesis

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12 December 2020

Stabilization of tubulin mRNAs by insulin and insulin-like growth factor I during neurite formation

1 reference

12 December 2020

Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts

1 reference

12 December 2020

Purkinje cell inclusions and 'atelencephaly' in 13q-chromosomal syndrome.

1 reference

12 December 2020

Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation

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12 December 2020

The distribution of tau in the mammalian central nervous system

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12 December 2020

Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells

1 reference

12 December 2020

Role of IRS-2 in insulin and cytokine signalling

1 reference

12 December 2020

Evidence for an important role of IGF-I and IGF-II for the early development of chick sympathetic neurons

1 reference

12 December 2020

Linked regularities in the development and evolution of mammalian brains

1 reference

12 December 2020

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

12 December 2020

Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds

1 reference

12 December 2020

Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene

1 reference

12 December 2020

In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell progenitors

1 reference

12 December 2020

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

1 reference

12 December 2020

Aging, metabolism, and Alzheimer disease: review and hypotheses

1 reference

12 December 2020

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

12 December 2020

The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family

1 reference

12 December 2020

Insulin and cognitive function in an elderly population. The Rotterdam Study

1 reference

12 December 2020

The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes.

1 reference

12 December 2020

The IRS-signalling system during insulin and cytokine action

1 reference

12 December 2020

Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

1 reference

12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

12 December 2020

Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons

1 reference

12 December 2020

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

12 December 2020

Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians

1 reference

12 December 2020

The cells and molecules that make a cerebellum.

1 reference

12 December 2020

Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

1 reference

12 December 2020

Tau protein pathology in neurodegenerative diseases

1 reference

12 December 2020

Cell production and cell death in the generation of variation in neuron number

1 reference

12 December 2020

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

12 December 2020

Effects of insulin-like growth factor 1 on olfactory neurogenesis in vivo and in vitro.

1 reference

12 December 2020

10.1523/JNEUROSCI.23-18-07084.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740672&resulttype=core&format=json

OpenCitations bibliographic resource ID

12 May 2020

3520698

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740672&resulttype=core&format=json

12 May 2020

PubMed publication ID

12904469

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3520698