Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling (Q30477015)

17 October 2017

Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling (English)

1 reference

17 October 2017

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1 reference

4

Manuel Estrada

1 reference

17 October 2017

Per Uhlén

1

1 reference

17 October 2017

Peter M Burch

2

1 reference

17 October 2017

Christina Ivins Zito

3

1 reference

17 October 2017

Barbara E Ehrlich

5

1 reference

17 October 2017

Anton M Bennett

6

1 reference

17 October 2017

language of work or name

English

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publication date

3 February 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

17 October 2017

1 reference

17 October 2017

103

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17 October 2017

7

1 reference

17 October 2017

2160-2165

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Germ-line and somatic PTPN11 mutations in human disease

17 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Calcium-calcineurin signaling in the regulation of cardiac hypertrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Calcium signalling: dynamics, homeostasis and remodelling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

NFAT signaling: choreographing the social lives of cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Calcium oscillations increase the efficiency and specificity of gene expression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

The transcription factor NF-ATc is essential for cardiac valve formation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Crystal structure of the tyrosine phosphatase SHP-2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Noonan syndrome. An update and review for the primary pediatrician

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

Signal transduction of a tissue interaction during embryonic heart development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413735

The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510876103

Hypertelorism With Turner Phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510876103

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510876103

Spectral analysis of calcium oscillations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510876103

SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510876103

Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510876103

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16461457

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0510876103

1 reference

17 October 2017

0 references

1 reference

17 October 2017

PubMed publication ID

16461457

1 reference