Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes (Q30480025)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17563369%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

title

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes (English)

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31 December 2019

1

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31 December 2019

Helene Barelli

3

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31 December 2019

André Padilla

5

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31 December 2019

Catherine A. Royer

8

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31 December 2019

author name string

Mahel Zeghouf

2

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31 December 2019

Jean-Christophe Zeeh

4

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31 December 2019

Bernard Guibert

6

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31 December 2019

Pierre Chardin

7

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31 December 2019

Jacqueline Cherfils

9

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31 December 2019

Alain Chavanieu

10

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31 December 2019

language of work or name

English

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publication date

11 June 2007

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Proceedings of the National Academy of Sciences of the United States of America

31 December 2019

published in

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31 December 2019

volume

104

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issue

25

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31 December 2019

page(s)

10370-10375

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Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains.

31 December 2019

cites work

1 reference

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Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance

20 June 2018

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ARF proteins: roles in membrane traffic and beyond

20 June 2018

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Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake

20 June 2018

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Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors

20 June 2018

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The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1.

20 June 2018

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RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

20 June 2018

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Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic

20 June 2018

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Multiple activities for Arf1 at the Golgi complex

20 June 2018

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Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

20 June 2018

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

20 June 2018

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Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors

20 June 2018

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Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements

20 June 2018

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

20 June 2018

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

20 June 2018

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Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

20 June 2018

1 reference

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Modulation of protein-protein interactions with small organic molecules

20 June 2018

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Binding of small molecules to an adaptive protein-protein interface

20 June 2018

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Endosome-specific localization and function of the ARF activator GNOM.

20 June 2018

1 reference

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

20 June 2018

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Inhibition of protein-protein association by small molecules: approaches and progress

20 June 2018

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Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D

20 June 2018

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Specificities for the small G proteins ARF1 and ARF6 of the guanine nucleotide exchange factors ARNO and EFA6.

20 June 2018

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Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers

20 June 2018

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20 June 2018

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Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain

20 June 2018

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Convergent solutions to binding at a protein-protein interface

20 June 2018

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Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain

20 June 2018

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Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching

20 June 2018

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A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.

20 June 2018

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Structure of the Sec7 domain of the Arf exchange factor ARNO

20 June 2018

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A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

20 June 2018

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Brefeldin A: insights into the control of membrane traffic and organelle structure

20 June 2018

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Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.

20 June 2018

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Structural Basis for Activation of ARF GTPase

21 January 2018

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Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.

21 January 2018

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Probing the physical basis for trp repressor-operator recognition

21 January 2018

1 reference

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Dual interaction of ADP ribosylation factor 1 with Sec7 domain and with lipid membranes during catalysis of guanine nucleotide exchange

21 January 2018

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12 December 2020

Identification of the first Rho-GEF inhibitor, TRIPalpha, which targets the RhoA-specific GEF domain of Trio

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12 December 2020

Resonance assignments and topology of the 15N, 13C labelled 23 kDa core domain of xenopus Mob1

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12 December 2020

Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0700773104

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17563369%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

0 references

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31 December 2019

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