Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport (Q30528638)

14 August 2017

Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport (English)

1 reference

14 August 2017

1 reference

Martin Steuble

1

1 reference

14 August 2017

Tu-My Diep

2

1 reference

14 August 2017

Philipp Schätzle

3

1 reference

14 August 2017

Alexander Ludwig

4

1 reference

14 August 2017

Mitsuo Tagaya

5

1 reference

14 August 2017

Beat Kunz

6

1 reference

14 August 2017

Peter Sonderegger

7

1 reference

14 August 2017

27 June 2012

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14 August 2017

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14 August 2017

1

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14 August 2017

8

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14 August 2017

761-774

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

14 August 2017

start time

2 September 2020

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3507217/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

1 reference

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Mechanisms of polarized membrane trafficking in neurons -- focusing in on endosomes

20 June 2018

1 reference

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Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin

20 June 2018

1 reference

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Amyloid precursor protein is trafficked and secreted via synaptic vesicles

20 June 2018

1 reference

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Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles

20 June 2018

1 reference

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ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

20 June 2018

1 reference

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The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

20 June 2018

1 reference

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APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle

20 June 2018

1 reference

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Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.

20 June 2018

1 reference

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The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.

20 June 2018

1 reference

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Calsyntenins mediate TGN exit of APP in a kinesin-1-dependent manner.

20 June 2018

1 reference

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Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

20 June 2018

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Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

20 June 2018

1 reference

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Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin

20 June 2018

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Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production

20 June 2018

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The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport

20 June 2018

1 reference

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Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.

20 June 2018

1 reference

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

20 June 2018

1 reference

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Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease

20 June 2018

1 reference

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Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

20 June 2018

1 reference

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Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.

20 June 2018

1 reference

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Alzheimer's disease beta-amyloid peptides are released in association with exosomes

20 June 2018

1 reference

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Calsyntenin-1 docks vesicular cargo to kinesin-1

20 June 2018

1 reference

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The X11 proteins, Abeta production and Alzheimer's disease.

20 June 2018

1 reference

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Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein

20 June 2018

1 reference

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Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited

20 June 2018

1 reference

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The non-amyloidogenic pathway: structure and function of alpha-secretases

20 June 2018

1 reference

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Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport

20 June 2018

1 reference

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Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation

20 June 2018

1 reference

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BACE1: the beta-secretase enzyme in Alzheimer's disease

20 June 2018

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20 June 2018

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The mechanism of axon growth: what we have learned from the cell adhesion molecule L1.

20 June 2018

1 reference

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Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism

20 June 2018

1 reference

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Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

20 June 2018

1 reference

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A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.

20 June 2018

1 reference

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The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Recycling of the cell adhesion molecule L1 in axonal growth cones.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Acidification of endocytic vesicles by an ATP-dependent proton pump

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Beta-amyloid precursor protein cleavage by a membrane-bound protease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Secretion of the β‐Amyloid Precursor Proteina

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Astrocyte and endothelial cell expression of ADAM 17 (TACE) in adult human CNS.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Novel tools for production and purification of recombinant adenoassociated virus vectors

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Intraneuronal compartments of the amyloid precursor protein.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507217

Trophic interactions between astroglial cells and hippocampal neurons in culture

26 November 2018

1 reference

12 December 2020

Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization

1 reference

12 December 2020

beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment

1 reference

12 December 2020

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

12 December 2020

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

1 reference

12 December 2020

Identifiers

DOI

10.1242/BIO.20121578

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

23213470

1 reference