Rapamycin extends murine lifespan but has limited effects on aging (Q30541884)

17 August 2017

Rapamycin extends murine lifespan but has limited effects on aging (English)

1 reference

17 August 2017

1 reference

1 reference

Valérie Gailus-Durner

38

Valérie Gailus-Durner

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Martin Hrabě de Angelis

39

Martin Hrabe de Angelis

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Devon P Ryan

Devon P Ryan

3

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Lillian Garrett

Lillian Garrett

10

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Lore Becker

Lore Becker

9

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Jan Rozman

Jan Rozman

20

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Sabine M. Hölter

Sabine M Hölter

14

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Cornelia Prehn

Cornelia Prehn

16

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Jochen Graw

Jochen Graw

28

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Martin Klingenspor

Martin Klingenspor

30

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Eckhard Wolf

Eckhard Wolf

34

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Gerhard Ehninger

27

Gerhard Ehninger

1 reference

17 August 2017

35

Wolfgang Wurst

1 reference

17 August 2017

26

Dirk H Busch

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17 August 2017

37

Helmut Fuchs

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17 August 2017

31

Thomas Klopstock

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17 August 2017

1

Frauke Neff

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17 August 2017

25

Raffi Bekeredjian

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17 August 2017

6

Thure Adler

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17 August 2017

17

Oliver Puk

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Juan Antonio Aguilar-Pimentel

17 August 2017

8

Juan Antonio Aguilar-Pimentel

1 reference

17 August 2017

15

Kristin Moreth

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17 August 2017

32

Markus Ollert

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17 August 2017

4

Marion Horsch

1 reference

17 August 2017

21

Beatrix Naton

1 reference

17 August 2017

Luciana Caminha Afonso

7

Luciana Caminha Afonso

1 reference

17 August 2017

29

Heinz Höfler

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17 August 2017

5

Susanne Schröder

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17 August 2017

40

Dan Ehninger

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17 August 2017

23

Jerzy Adamski

1 reference

17 August 2017

Diana Flores-Dominguez

2

1 reference

17 August 2017

Wolfgang Hans

11

1 reference

17 August 2017

Moritz M Hettich

12

1 reference

17 August 2017

Richard Holtmeier

13

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17 August 2017

Ildikó Rácz

18

1 reference

17 August 2017

Birgit Rathkolb

19

1 reference

17 August 2017

Rainer Ordemann

22

1 reference

17 August 2017

Johannes Beckers

24

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17 August 2017

Jörg Stypmann

33

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17 August 2017

Andreas Zimmer

36

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17 August 2017

language of work or name

English

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publication date

25 July 2013

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Journal of Clinical Investigation

17 August 2017

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17 August 2017

123

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17 August 2017

8

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17 August 2017

3272-3291

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Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Adult-onset fluoxetine treatment does not improve behavioral impairments and may have adverse effects on the Ts65Dn mouse model of Down syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Rapamycin slows aging in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Cardiac aging in mice and humans: the role of mitochondrial oxidative stress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Rapamycin extends maximal lifespan in cancer-prone mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

An emerging role of mTOR in lipid biosynthesis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Systemic first-line phenotyping

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Echocardiographic assessment of global left ventricular function in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

CellProfiler: free, versatile software for automated biological image analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Extension of chronological life span in yeast by decreased TOR pathway signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Genetics: influence of TOR kinase on lifespan in C. elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Experience-induced neurogenesis in the senescent dentate gyrus.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Gerontological data of C57BL/6J mice. II. Changes in blood cell counts in the course of natural aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

mTOR inhibition and erythropoiesis: microcytosis or anaemia?

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

The effect of fasting and refeeding on thyroid follicule structure and thyroid hormone levels in young and old rats.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Investigation of age-related cognitive decline using mice as a model system: behavioral correlates

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Rapamycin's resurrection: a new way to target the cancer cell cycle

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3726163

Distribution of sirolimus in rat tissue

26 November 2018

1 reference

12 December 2020

Hematologic and clinical chemistry findings in control BALB/c and C57BL/6 mice

1 reference

12 December 2020

Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system

1 reference

12 December 2020

Luteinizing hormone and testosterone secretion in young and old male mice

1 reference

12 December 2020

Mesolimbicocortical dopamine terminal fields are necessary for normal locomotor and investigatory exploration in rats

1 reference

12 December 2020

Expression of tissue inhibitor of matrix metalloproteinase-1 in aging of transgenic mouse liver

1 reference

12 December 2020

A rotarod suitable for quantitative measurements of motor incoordination in naive mice

1 reference

12 December 2020

Pathology of aging B6;129 mice

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI67674

1 reference

17 August 2017

1 reference

17 August 2017

1 reference