Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy (Q30557792)

19 August 2017

Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy (English)

1 reference

19 August 2017

Caenorhabditis elegans

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1 reference

1 reference

Hongkyun Kim

2

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author name string

Kelly Hyunju Oh

series ordinal

1

1 reference

PMCID

3839758

19 August 2017

language of work or name

English

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publication date

4 November 2013

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Proceedings of the National Academy of Sciences of the United States of America

19 August 2017

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19 August 2017

110

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19 August 2017

47

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19 August 2017

19024-19029

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Regulation of organismal proteostasis by transcellular chaperone signaling

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Duchenne muscular dystrophy models show their age.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Modeling human diseases in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Distinct genetic regions modify specific muscle groups in muscular dystrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Widespread protein aggregation as an inherent part of aging in C. elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Mechanisms of muscle weakness in muscular dystrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Chaperone-assisted selective autophagy is essential for muscle maintenance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Role of the sarcomeric Z-disc in the pathogenesis of cardiomyopathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Dysfunction of mitochondria and sarcoplasmic reticulum in the pathogenesis of collagen VI muscular dystrophies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

The insulin paradox: aging, proteotoxicity and neurodegeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

The measurement and analysis of age-related changes in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Stressing the role of FoxO proteins in lifespan and disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

The role of free radicals in the pathophysiology of muscular dystrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Molecular mechanisms of muscular dystrophies: old and new players

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Opposing activities protect against age-onset proteotoxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Proteome analysis of the dystrophin-deficient MDX diaphragm reveals a drastic increase in the heat shock protein cvHSP.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Proteomic analysis of mdx skeletal muscle: Great reduction of adenylate kinase 1 expression and enzymatic activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Function and genetics of dystrophin and dystrophin-related proteins in muscle

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Impaired mitochondrial oxidative phosphorylation in skeletal muscle of the dystrophin-deficient mdx mouse.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839758

Hypertrophic response of Duchenne and limb-girdle muscular dystrophies is associated with activation of Akt pathway

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1308866110

Mutations in the Caenorhabditis elegans dystrophin-like gene dys-1 lead to hyperactivity and suggest a link with cholinergic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1308866110

Mutations in the dystrophin-like dys-1 gene of Caenorhabditis elegans result in reduced acetylcholinesterase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1308866110

Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1308866110

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1308866110

Genetic background influences muscular dystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1308866110

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1308866110

Evidence of oxidative stress in mdx mouse muscle: studies of the pre-necrotic state

21 January 2018

1 reference

12 December 2020

Muscle cells from mdx mice have an increased susceptibility to oxidative stress

1 reference

12 December 2020

Reporter transgenes for study of oxidant stress in Caenorhabditis elegans

1 reference

12 December 2020

Mitochondria and aging: dilution is the solution

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1308866110

1 reference

19 August 2017

0 references

1 reference

19 August 2017

1 reference

PMCID

3839758