A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production (Q30577278)

22 August 2017

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production (English)

1 reference

22 August 2017

1 reference

16

1 reference

22 August 2017

Amanda L Soohoo

6

0 references

Manojkumar A Puthenveedu

Manojkumar A Puthenveedu

13

0 references

Mikael Simons

Mikael Simons

11

0 references

Jonas Ries

Jonas Ries

12

0 references

John Anthony Hardy

14

John Hardy

1 reference

22 August 2017

Vinod Udayar

1

1 reference

22 August 2017

Virginie Buggia-Prévot

2

1 reference

22 August 2017

Rita L Guerreiro

3

1 reference

22 August 2017

Gabriele Siegel

4

1 reference

22 August 2017

Naresh Rambabu

5

1 reference

22 August 2017

Moorthi Ponnusamy

7

1 reference

22 August 2017

Barbara Siegenthaler

8

1 reference

22 August 2017

Jitin Bali

9

1 reference

22 August 2017

AESG

10

1 reference

22 August 2017

Gopal Thinakaran

15

1 reference

22 August 2017

1 December 2013

1 reference

22 August 2017

1 reference

22 August 2017

5

1 reference

22 August 2017

6

1 reference

22 August 2017

1536-1551

1 reference

describes a project that uses

22 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4004174/fullTextXML

inferred from PubMed Central ID database lookup

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Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

14 July 2018

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

14 July 2018

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Evi5 promotes collective cell migration through its Rab-GAP activity

14 July 2018

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Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion

14 July 2018

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Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network

14 July 2018

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TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

14 July 2018

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Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.

14 July 2018

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Alzheimer mechanisms and therapeutic strategies

14 July 2018

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Retromers in Alzheimer's disease

14 July 2018

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Membrane trafficking pathways in Alzheimer's disease

14 July 2018

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Illuminating the functional and structural repertoire of human TBC/RABGAPs.

14 July 2018

1 reference

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Resolving controversies on the path to Alzheimer's therapeutics

14 July 2018

1 reference

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ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

14 July 2018

1 reference

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α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential

14 July 2018

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14 July 2018

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Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

14 July 2018

1 reference

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Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

14 July 2018

1 reference

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Rab27a and Rab27b control different steps of the exosome secretion pathway

14 July 2018

1 reference

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APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle

14 July 2018

1 reference

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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

14 July 2018

1 reference

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Function, regulation and therapeutic properties of beta-secretase (BACE1).

14 July 2018

1 reference

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Amyloid precursor protein trafficking, processing, and function

14 July 2018

1 reference

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Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Building gamma-secretase: the bits and pieces

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Presenilin: running with scissors in the membrane

14 July 2018

1 reference

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Functional dissection of Rab GTPases involved in primary cilium formation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

14 July 2018

1 reference

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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

14 July 2018

1 reference

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Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1

14 July 2018

1 reference

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Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

14 July 2018

1 reference

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GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.

14 July 2018

1 reference

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Alzheimer's disease beta-amyloid peptides are released in association with exosomes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Model-guided microarray implicates the retromer complex in Alzheimer's disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Targeting Rab GTPases to distinct membrane compartments

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

A cell biological perspective on Alzheimer's disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Rab GTPases, intracellular traffic and disease.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

14 July 2018

The Rab GTPase family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Rab proteins as membrane organizers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-golgi network

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Receptor-coupled amyloid precursor protein processing

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Endosome acidification and the pathways of receptor-mediated endocytosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

SnapShot: Mammalian Rab Proteins in Endocytic Trafficking

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Revised criteria for Alzheimer's disease: what are the lessons for clinicians?

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Recycling endosomes in neuronal membrane traffic.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

A complete genetic analysis of neuronal Rab3 function.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Mutant presenilin (A260V) affects Rab8 in PC12D cell

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004174

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24373285

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/24373285

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CELREP.2013.12.005

1 reference

release_ibuuknqw5fcyzemg7ew7scielm

22 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ibuuknqw5fcyzemg7ew7scielm

24 November 2022

mapped directly with Wikidata item

1 reference

22 August 2017

PubMed publication ID

24373285

1 reference