Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization (Q30579125)

16 September 2017

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization (English)

1 reference

16 September 2017

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1 reference

1

1 reference

16 September 2017

22

1 reference

16 September 2017

23

1 reference

Rodrigo Leite de Oliveira

16 September 2017

Rodrigo Leite de Oliveira

3

0 references

Patrick J Pollard

Patrick Pollard

9

0 references

Frederik De Smet

Frederik De Smet

11

0 references

Aernout Luttun

Aernout Luttun

15

0 references

Thomas Schmidt

Thomas Schmidt

5

0 references

Maria Grazia Lampugnani

Maria Grazia Lampugnani

20

0 references

Patrick H. Maxwell

Patrick Maxwell

24

0 references

Elisabetta Dejana

21

Elisabetta Dejana

1 reference

16 September 2017

7

Ya-Min Tian

1 reference

16 September 2017

25

Peter Carmeliet

1 reference

16 September 2017

16

Sabine Wyns

1 reference

16 September 2017

6

Bart Jonckx

1 reference

16 September 2017

4

Sonja Loges

1 reference

16 September 2017

Carmen Ruiz De Almodovar

10

Carmen Ruiz de Almodovar

1 reference

16 September 2017

12

Stefan Vinckier

1 reference

16 September 2017

Julian Aragones Lopez

13

Julián Aragonés

1 reference

16 September 2017

17

Benedicte Jordan

1 reference

16 September 2017

19

Bernard Gallez

1 reference

16 September 2017

Daniela Dettori

2

1 reference

16 September 2017

Anthony A Lanahan

8

1 reference

16 September 2017

Koen Debackere

14

1 reference

16 September 2017

Alberto Pisacane

18

1 reference

16 September 2017

language of work or name

English

0 references

publication date

12 February 2009

1 reference

16 September 2017

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16 September 2017

136

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5

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16 September 2017

839-851

1 reference

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

16 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

A role for VEGF as a negative regulator of pericyte function and vessel maturation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Modes of resistance to anti-angiogenic therapy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Perivascular nitric oxide gradients normalize tumor vasculature

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Pericytes: gatekeepers in tumour cell metastasis?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Hypoxia-driven selection of the metastatic phenotype

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Hypoxia inducible factor-2alpha in cancer.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Cellular abnormalities of blood vessels as targets in cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Targeting HIF-1 for cancer therapy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037868

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19217150

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19217150

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypoxia-inducible transcription factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin A1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19217150

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2009.01.020

1 reference

16 September 2017

1 reference

16 September 2017

1 reference