The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth (Q80212331)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

review article

1 reference

title

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

author name string

Gavin Thurston

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Irene Noguera-Troise

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

George D Yancopoulos

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

publication date

1 May 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

page(s)

327-331

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17457300%20AND%20SRC:MED&resulttype=core&format=json

Vascular endothelial growth factor as a target for anticancer therapy

29 December 2019

cites work

1 reference

VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene- based discovery of the next generation of angiogenesis targets

31 March 2020

1 reference

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

31 March 2020

1 reference

VEGF-Trap: a VEGF blocker with potent antitumor effects

31 March 2020

1 reference

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

31 March 2020

1 reference

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

31 March 2020

1 reference

Angiogenesis as a therapeutic target

31 March 2020

1 reference

Lessons from phase III clinical trials on anti-VEGF therapy for cancer

31 March 2020

1 reference

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

31 March 2020

1 reference

Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches.

31 March 2020

1 reference

Notch signaling: cell fate control and signal integration in development

31 March 2020

1 reference

Notch signaling in vascular development

31 March 2020

1 reference

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

31 March 2020

1 reference

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

31 March 2020

1 reference

From gut homeostasis to cancer

31 March 2020

1 reference

Notch and NOXA-related pathways in melanoma cells.

31 March 2020

1 reference

Notch signaling in cancer

31 March 2020

1 reference

Notch signaling during vascular development

31 March 2020

1 reference

Notch1 is essential for postimplantation development in mice.

31 March 2020

1 reference

Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

31 March 2020

1 reference

Isolation and characterization of the notch ligand delta4.

31 March 2020

1 reference

Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

31 March 2020

1 reference

Molecular cloning of delta-4, a new mouse and human Notch ligand

31 March 2020

1 reference

Dosage-sensitive requirement for mouse Dll4 in artery development

31 March 2020

1 reference

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

31 March 2020

1 reference

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

31 March 2020

1 reference

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

31 March 2020

1 reference

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

31 March 2020

1 reference

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

31 March 2020

1 reference

Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

31 March 2020

1 reference

Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer

31 March 2020

1 reference

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

31 March 2020

1 reference

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion

31 March 2020

1 reference

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

31 March 2020

1 reference

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

31 March 2020

1 reference

Cellular abnormalities of blood vessels as targets in cancer

31 March 2020

1 reference

Periodic Delta-like 4 expression in developing retinal arteries.

31 March 2020

1 reference

Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting

31 March 2020

1 reference

The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.

31 March 2020

1 reference

Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis.

31 March 2020

1 reference