Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase (Q30647316)

18 September 2017

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase (English)

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18 September 2017

13

Dieter Häussinger

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18 September 2017

Natalia Qvartskhava

1

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18 September 2017

Philipp A Lang

2

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18 September 2017

Boris Görg

3

1 reference

18 September 2017

Vitaly I Pozdeev

4

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18 September 2017

Marina Pascual Ortiz

5

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18 September 2017

Karl S Lang

6

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18 September 2017

Hans J Bidmon

7

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18 September 2017

Elisabeth Lang

8

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18 September 2017

Christina B Leibrock

9

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18 September 2017

Diran Herebian

10

1 reference

18 September 2017

Johannes G Bode

11

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18 September 2017

Florian Lang

12

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18 September 2017

language of work or name

English

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publication date

13 April 2015

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Proceedings of the National Academy of Sciences of the United States of America

18 September 2017

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18 September 2017

112

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18 September 2017

17

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18 September 2017

5521-5526

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Patients with manifest hepatic encephalopathy can reveal impaired thermal perception.

18 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Microglial proliferation in the brain of chronic alcoholics with hepatic encephalopathy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

The slowed brain: cortical oscillatory activity in hepatic encephalopathy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Inflammation and hepatic encephalopathy.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Update on cerebral uptake of blood ammonia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Gene expression profiling in the cerebral cortex of patients with cirrhosis with and without hepatic encephalopathy.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Branched-chain amino acids and muscle ammonia detoxification in cirrhosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Pericentral activity of alpha-fetoprotein enhancer 3 and glutamine synthetase upstream enhancer in the adult liver are regulated by β-catenin in mice.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Mechanisms underlying inflammation in neurodegeneration

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Pathogenetic mechanisms of hepatic encephalopathy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Glutamine metabolism and signaling in the liver

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Conditional deletion of beta-catenin reveals its role in liver growth and regeneration

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Astrocyte dysfunction in neurological disorders: a molecular perspective

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Deficits in cortico-striatal synaptic plasticity and behavioral habituation in rats with portacaval anastomosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Cognitive outcome in urea cycle disorders

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Expression of glutamine synthetase in macrophages

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Nitrogen metabolism in liver: structural and functional organization and physiological relevance

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Ammonia-induced astrocyte swelling in primary culture

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Colocalization in pericentral hepatocytes in adult mice and similarity in developmental expression pattern of ornithine aminotransferase and glutamine synthetase mRNA

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain, and skeletal muscle

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Hepatocyte Heterogeneity in the Metabolism of Amino Acids and Ammonia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418919

Hepatic encephalopathy: clinical aspects and pathogenetic concept

14 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Oxidative stress and hippocampus in a low-grade hepatic encephalopathy model: protective effects of curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Portal hypertension in 18-month-old rats: memory deficits and brain metabolic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Preventive effect of N-acetyl-L-cysteine on oxidative stress and cognitive impairment in hepatic encephalopathy following bile duct ligation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Lipopolysaccharide-induced tyrosine nitration and inactivation of hepatic glutamine synthetase in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Congenital glutamine deficiency with glutamine synthetase mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Localization of the ammonium transporters, Rh B glycoprotein and Rh C glycoprotein, in the mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Memory function in early hepatic encephalopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Motor impairment in liver cirrhosis without and with minimal hepatic encephalopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423968112

Reversible inhibition of mammalian glutamine synthetase by tyrosine nitration

21 January 2018

1 reference

12 December 2020

Locomotor impairment and cerebrocortical oxidative stress in portal vein ligated rats in vivo

1 reference

12 December 2020

Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver

1 reference

12 December 2020

Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy

1 reference

12 December 2020

Hepatocyte heterogeneity in ammonia metabolism: impairment of glutamine synthesis in CCl4 induced liver cell necrosis with no effect on urea synthesis

1 reference

12 December 2020

Microglia activation in hepatic encephalopathy in rats and humans

1 reference

12 December 2020

Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle

1 reference

12 December 2020

Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonaemia in chronic liver disease

1 reference

12 December 2020

GLUTAMINE SYNTHETASE ACTIVITY IN RAT LIVER AFTER PORTACAVAL SHUNT

1 reference

12 December 2020

Immunohistochemical localization of carbamoyl-phosphate synthetase (ammonia) in adult rat liver; evidence for a heterogeneous distribution

1 reference

12 December 2020

Changes in distribution and activity of glutamine synthetase in carbon tetrachloride-induced cirrhosis in the rat: potential role in hyperammonemia

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1423968112

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18 September 2017

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1 reference

18 September 2017

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