Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells (Q30781595)

26 June 2017

title

Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells (English)

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26 June 2017

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Zhen Y Jiang

1

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26 June 2017

Qiong L Zhou

2

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26 June 2017

John Holik

3

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26 June 2017

Shraddha Patel

4

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26 June 2017

John Leszyk

5

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26 June 2017

Kerri Coleman

6

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26 June 2017

My Chouinard

7

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26 June 2017

Michael P Czech

8

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26 June 2017

language of work or name

English

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publication date

30 March 2005

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Journal of Biological Chemistry

26 June 2017

published in

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26 June 2017

volume

280

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26 June 2017

issue

22

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26 June 2017

page(s)

21622-21628

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

26 June 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Akt regulates growth by directly phosphorylating Tsc2

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

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A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

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Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

21 January 2018

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WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

21 January 2018

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21 January 2018

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WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

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21 January 2018

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

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Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M414464200

1 reference

release_xdvhdnfionfirox4nmyflis6de

26 June 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/xdvhdnfionfirox4nmyflis6de

mapped directly with Wikidata item

24 November 2022

based on heuristic

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