Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling. (Q30823978)

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20 December 2019

title

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling (English)

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20 December 2019

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1

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20 December 2019

Erinna Lee

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20 December 2019

Shenggen Yao

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David De Souza

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Nicos A. Nicola

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Donald Metcalf

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Raymond S Norton

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20 December 2019

author name string

Alessandro D Uboldi

2

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20 December 2019

Joanne E McCoubrie

3

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20 December 2019

Chunxiao C Wang

4

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20 December 2019

Sandra Mifsud

8

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20 December 2019

Manuel Baca

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20 December 2019

language of work or name

English

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publication date

29 October 2003

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Journal of Biological Chemistry

20 December 2019

published in

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volume

279

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20 December 2019

issue

3

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20 December 2019

page(s)

2125-2134

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Receptor recognition by gp130 cytokines

20 December 2019

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LIF: lots of interesting functions

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Evidence for the formation of a heterotrimeric complex of leukaemia inhibitory factor with its receptor subunits in solution

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The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor

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Effects of leukaemia inhibitory factor on embryo implantation in the mouse

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An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M.

21 January 2018

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Affinity maturation of human growth hormone by monovalent phage display

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Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells

21 January 2018

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Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.

21 January 2018

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Phage display for selection of novel binding peptides

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A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).

21 January 2018

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

21 January 2018

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Resonance assignments, secondary structure and topology of leukaemia inhibitory factor in solution.

21 January 2018

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Calculation of protein extinction coefficients from amino acid sequence data

21 January 2018

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A fusion protein system for the recombinant production of short disulfide-containing peptides.

21 January 2018

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The program XEASY for computer-supported NMR spectral analysis of biological macromolecules

21 January 2018

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1H, 13C and 15N chemical shift referencing in biomolecular NMR

21 January 2018

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Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

21 January 2018

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Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor

21 January 2018

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The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation.

21 January 2018

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Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display

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Additivity of mutational effects in proteins

21 January 2018

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Solution structure of leukemia inhibitory factor

21 January 2018

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Mutations in the immunoglobulin-like domain of gp190, the leukemia inhibitory factor (LIF) receptor, increase or decrease its affinity for LIF.

21 January 2018

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Leukemia Inhibitory Factor (LIF), Cardiotrophin-1, and Oncostatin M Share Structural Binding Determinants in the Immunoglobulin-like Domain of LIF Receptor

21 January 2018

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A major binding protein for leukemia inhibitory factor in normal mouse serum: identification as a soluble form of the cellular receptor

21 January 2018

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Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity

21 January 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

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Localizing the NADP+ binding site on the MurB enzyme by NMR.

21 January 2018

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Chemical shifts as a tool for structure determination

21 January 2018

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Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists

21 January 2018

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Leukemia inhibitory factor, leukemia inhibitory factor receptor, and glycoprotein 130 in rhesus monkey uterus during menstrual cycle and early pregnancy

21 January 2018

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In vivo effect of leukemia inhibitory factor (LIF) and an anti-LIF polyclonal antibody on murine embryo and fetal development following exposure at the time of transcervical blastocyst transfer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M310103200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585833%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

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