NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways (Q30994890)

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English	NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways (English)

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

reactive oxygen species

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

3

object named as

Xiuqing Huang

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

author name string

Huiping Yuan

1

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Xiaoyong Zhang

2

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Yonggang Lu

4

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Weiqing Tang

5

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Yong Man

6

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Shu Wang

7

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

Jianzhong Xi

8

1 reference

Europe PubMed Central

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2 October 2017

Jian Li

9

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

language of work or name

0 references

publication date

29 December 2010

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Europe PubMed Central

PMC publication ID

2 October 2017

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

5

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

12

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

e15726

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

copyright license

Creative Commons Attribution 4.0 International

29 December 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells.

1 reference

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21 June 2018

Oxidative stress and oxidative damage in carcinogenesis

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21 June 2018

Abnormalities in insulin secretion in type 2 diabetes mellitus

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21 June 2018

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

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21 June 2018

The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1.

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21 June 2018

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

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21 June 2018

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

1 reference

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21 June 2018

New insights into fatty acid modulation of pancreatic beta-cell function.

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21 June 2018

The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation

1 reference

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21 June 2018

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The pathobiology of diabetic complications: a unifying mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Role of oxidative stress in pancreatic beta-cell dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

2 references

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21 June 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

25 November 2018

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

1 reference

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21 June 2018

Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids

1 reference

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21 June 2018

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

A central role for JNK in obesity and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012098

21 June 2018

Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: protective role of arjunolic acid

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21 January 2018

Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015726

21 January 2018

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21209957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0015726

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

2010PLoSO...515726Y

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

ResearchGate publication ID

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