Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans (Q34338020)

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English	Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans	scientific article

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans (English)

1 reference

Europe PubMed Central

1 August 2017

1 reference

based on heuristic

inferred from title

author name string

Derek K Hagman

1

1 reference

Europe PubMed Central

1 August 2017

Lori B Hays

2

1 reference

Europe PubMed Central

1 August 2017

Susan D Parazzoli

3

1 reference

Europe PubMed Central

1 August 2017

Vincent Poitout

4

1 reference

Europe PubMed Central

1 August 2017

language of work or name

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publication date

8 June 2005

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Europe PubMed Central

1 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

1 August 2017

280

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Europe PubMed Central

1 August 2017

37

1 reference

Europe PubMed Central

1 August 2017

32413-32418

1 reference

Europe PubMed Central

1 August 2017

A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Conserved transcriptional regulatory domains of the pdx-1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Intracellular signal transduction pathways activated by ceramide and its metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

The islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Regulation of the pdx1 gene promoter in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Regulation of insulin gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Regulation of insulin gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Signal transduction of stress via ceramide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

The role of the insulin control element and RIPE3b1 activators in glucose-stimulated transcription of the insulin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1361267

6 July 2018

Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506000200

21 January 2018

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506000200

21 January 2018

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506000200

21 January 2018

Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506000200

21 January 2018

Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506000200

21 January 2018

Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506000200

21 January 2018

Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506000200

21 January 2018

Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506000200

21 January 2018

Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944145

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M506000200

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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