Ecstasy: are animal data consistent between species and can they translate to humans? (Q31033315)

28 June 2017

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title

Ecstasy: are animal data consistent between species and can they translate to humans? (English)

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28 June 2017

Neil Easton

1

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28 June 2017

Charles A Marsden

series ordinal

2

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28 June 2017

language of work or name

English

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publication date

1 March 2006

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Journal of Psychopharmacology

28 June 2017

published in

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28 June 2017

volume

20

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28 June 2017

issue

2

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28 June 2017

page(s)

194-210

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MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion

28 June 2017

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21 January 2018

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Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: influence of ambient temperature

21 January 2018

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Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates

21 January 2018

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Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") users

21 January 2018

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Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion.

21 January 2018

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MDMA ('Ecstasy') and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats.

21 January 2018

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MDMA ("ecstasy"), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat.

21 January 2018

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Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood

21 January 2018

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5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine

21 January 2018

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Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function

21 January 2018

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The hyperthermic and neurotoxic effects of ‘Ecstasy’ (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype

21 January 2018

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In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism.

21 January 2018

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In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine

21 January 2018

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Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administration

21 January 2018

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A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain

21 January 2018

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Preliminary evidence of the cardiovascular effects of polysubstance misuse in nightclubs.

21 January 2018

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‘Ecstasy’ Psychosis and Flashbacks

21 January 2018

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Persistent loss of thermoregulation in the rat induced by 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") but not by fenfluramine.

21 January 2018

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The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.

21 January 2018

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Effect of SCH 23390 on (+/-)-3,4-methylenedioxymethamphetamine hyperactivity and self-administration in rats

21 January 2018

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Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.

21 January 2018

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Non-linear pharmacokinetics of MDMA ('ecstasy') in humans

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Pharmacology of MDMA in Humans

21 January 2018

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Validity of in vivo [123I]beta-CIT SPECT in detecting MDMA-induced neurotoxicity in rats

21 January 2018

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A Clinical Plan for MDMA (Ecstasy) in the Treatment of Posttraumatic Stress Disorder (PTSD): Partnering with the FDA

21 January 2018

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Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy).

21 January 2018

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A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice

21 January 2018

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3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose

21 January 2018

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An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA

21 January 2018

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Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse

21 January 2018

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Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice

21 January 2018

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Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys

21 January 2018

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Effects of methylenedioxymethamphetamine on the release of monoamines from rat brain slices

21 January 2018

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Interactions of methylenedioxymethamphetamine with monoamine transmitter release mechanisms in rat brain slices.

21 January 2018

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Long-term changes in social interaction and reward following repeated MDMA administration to adolescent rats without accompanying serotonergic neurotoxicity

21 January 2018

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Ecstasy use: cognitive deficits related to dosage rather than self-reported problematic use of the drug

21 January 2018

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Neuropsychological evidence of a relatively selective profile of temporal dysfunction in drug-free MDMA ("ecstasy") polydrug users

21 January 2018

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Long-lasting effects of (+/-)3,4-methylenedioxymethamphetamine (ecstasy) on serotonin system function in humans.

21 January 2018

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Effects of (+/-) 3,4-methylene-dioxymethamphetamine (ecstasy) on dopamine system function in humans

21 January 2018

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The serotonin syndrome and its treatment

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Molecular genetics of the debrisoquin-sparteine polymorphism

21 January 2018

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Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate

21 January 2018

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Memory impairment suggests hippocampal dysfunction in abstinent ecstasy users

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response

21 January 2018

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The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: evidence for the protective effect of chlormethiazole

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion

21 January 2018

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Ecstasy and the dance of death

21 January 2018

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Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine.

21 January 2018

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Acute and long-term consequences of single MDMA administration in relation to individual anxiety levels in the rat.

21 January 2018

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Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its congeners

21 January 2018

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Preliminary evidence of hippocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effects

21 January 2018

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Chronic treatment with supraphysiological levels of corticosterone enhances D-MDMA-induced dopaminergic neurotoxicity in the C57BL/6J female mouse

21 January 2018

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Restraint as a stressor in mice: against the dopaminergic neurotoxicity of D-MDMA - low body weight mitigates restraint-induced hypothermia and consequent neuroprotection

21 January 2018

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Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

21 January 2018

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Serotonergic neurotoxic metabolites of ecstasy identified in rat brain.

21 January 2018

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Effects of the selective 5-HT2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats

21 January 2018

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Functional consequences of perinatal exposure to 3,4-methylenedioxymethamphetamine in rat brain

21 January 2018

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How strong is the evidence that brain serotonin neurons are damaged in human users of ecstasy?

21 January 2018

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MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females

21 January 2018

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Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function?

21 January 2018

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The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine ('Ecstasy') in healthy volunteers.

21 January 2018

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Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes

21 January 2018

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Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity.

21 January 2018

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MDMA ("ecstasy") and panic disorder: induction by a single dose

21 January 2018

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Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy').

21 January 2018

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Serotonin neurotoxicity after (+/-)3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy"): a controlled study in humans.

21 January 2018

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Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings.

21 January 2018

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Altered neuroendocrine and behavioral responses to m-chlorophenylpiperazine in 3,4-methylenedioxymethamphetamine (MDMA) users.

21 January 2018

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Chronic MDMA (ecstasy) use, cognition and mood.

21 January 2018

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Increased anxiety 3 months after brief exposure to MDMA ("Ecstasy") in rats: association with altered 5-HT transporter and receptor density

21 January 2018

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Long term psychiatric and cognitive effects of MDMA use.

21 January 2018

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Chronic paranoid psychosis after misuse of MDMA ("ecstasy")

21 January 2018

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Diversity of psychopathology associated with use of 3,4-methylenedioxymethamphetamine ('Ecstasy')

21 January 2018

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Neurochemistry and neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").

21 January 2018

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Differential toxic effects of methamphetamine (METH) and methylenedioxymethamphetamine (MDMA) in multidrug-resistant (mdr1a) knockout mice.

21 January 2018

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Behavioural analysis of the acute and chronic effects of MDMA treatment in the rat.

21 January 2018

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A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation

21 January 2018

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The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats

21 January 2018

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The role of temperature, stress, and other factors in the neurotoxicity of the substituted amphetamines 3,4-methylenedioxymethamphetamine and fenfluramine

21 January 2018

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Effects of intracerebroventricular administration of 5-(glutathion-S-yl)-alpha-methyldopamine on brain dopamine, serotonin, and norepinephrine concentrations in male Sprague-Dawley rats.

21 January 2018

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2,5-Bis-(glutathion-S-yl)-alpha-methyldopamine, a putative metabolite of (+/-)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations

21 January 2018

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Functional MRI study of working memory in MDMA users

21 January 2018

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Memory deficits associated with recreational use of "ecstasy" (MDMA).

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Ecstasy (MDMA): a review of its possible persistent psychological effects

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Increased anxiety and impaired memory in rats 3 months after administration of 3,4-methylenedioxymethamphetamine ("ecstasy").

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3,4-methylenedioxymethamphetamine.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Repeated exposure to methylenedioxymethamphetamine (MDMA) alters nucleus accumbens neuronal responses to dopamine and serotonin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Cardiovascular and sympathetic responses and reflex changes elicited by MDMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy').

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Cognitive performance in recreational users of MDMA of 'ecstasy': evidence for memory deficits

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Neuroendocrine and mood responses to intravenous L-tryptophan in 3,4-methylenedioxymethamphetamine (MDMA) users. Preliminary observations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Neurotoxic amphetamine analogues: effects in monkeys and implications for humans

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881106061153

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration.

21 January 2018

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Toxicodynamics and long-term toxicity of the recreational drug, 3, 4-methylenedioxymethamphetamine (MDMA, 'Ecstasy').

21 January 2018

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Hyperthermic and neurotoxic effect of 3,4-methylenedioxymethamphetamine (MDMA) in guinea pigs

21 January 2018

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The role of 5-HT in the impairment of thermoregulation observed in rats administered MDMA ('ecstasy') when housed at high ambient temperature

21 January 2018

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Reserpine attenuates D-amphetamine and MDMA-induced transmitter release in vivo: a consideration of dose, core temperature and dopamine synthesis.

21 January 2018

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Differential effect of dietary selenium on the long-term neurotoxicity induced by MDMA in mice and rats

21 January 2018

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Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurones

21 January 2018

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A bitter pill. Overview of ecstasy (MDMA, MDA) related fatalities

21 January 2018

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Neurotoxicity of MDMA: neurochemical effects

21 January 2018

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Direct central effects of acute methylenedioxymethamphetamine on serotonergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Contribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Biomarkers of adult and developmental neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

The adolescent brain and age-related behavioral manifestations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Neurotoxicity of MDMA (ecstasy): beyond metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Behavioral and neurochemical effects of prenatal methylenedioxymethamphetamine (MDMA) exposure in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Sub-acute effects of MDMA (+/-3,4-methylenedioxymethamphetamine, "ecstasy") on mood: evidence of gender differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Caveat emptor: editors beware

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Psychological and Cardiovascular Effects and Short-Term Sequelae of MDMA (“Ecstasy”) in MDMA-Naïve Healthy Volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Exposure to 3,4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Alterations in diurnal and nocturnal locomotor activity in rats treated with a monoamine-depleting regimen of methamphetamine or 3,4-methylenedioxymethamphetamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Working memory deficits in current and previous users of MDMA ('ecstasy').

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Visuospatial memory impairments in users of MDMA ('ecstasy').

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Verbal working memory deficits in current and previous users of MDMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Visuo-spatial working memory deficits in current and former users of MDMA ('ecstasy').

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Ecstasy pill testing: harm minimization gone too far?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

The neurochemical and stimulatory effects of putative metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

Acute Toxicity of 3,4-Methylenedioxymethamphetamine (MDMA) in Sprague–Dawley and Dark Agouti Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881106061153

21 January 2018

Identifiers

DOI

10.1177/0269881106061153

1 reference

release_azyymouuqzbo5lnsknjjqfllky

28 June 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/azyymouuqzbo5lnsknjjqfllky

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference