Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders (Q32167631)

6 July 2017

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title

Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders (English)

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6 July 2017

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Prchal JT

1

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6 July 2017

1 January 2001

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6 July 2017

Seminars in Hematology

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6 July 2017

38

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6 July 2017

1 Suppl 2

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6 July 2017

10-20

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The mechanism of action of erythropoietin

6 July 2017

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Oxygen sensing and molecular adaptation to hypoxia

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Hypoxia, clonal selection, and the role of HIF-1 in tumor progression

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Purification and characterization of hypoxia-inducible factor 1

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Jak2 is essential for signaling through a variety of cytokine receptors

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Erythropoiesis, serum erythropoietin, and serum IGF-I in rats during accelerated growth

1 reference

https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Prolonged hypoxia induced by the reduction of maternal uterine blood flow alters insulin-like growth factor-binding protein-1 (IGFBP-1) and IGFBP-2 gene expression in the ovine fetus

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Developmental consequences of the renin-angiotensin system

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Angiotensin II receptor-mediated proliferation of cultured human fetal mesangial cells

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Enalapril treatment of posttransplant erythrocytosis: efficacy independent of circulating erythropoietin levels

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Detection of mutant hemoglobins with altered affinity for oxygen. A simplified technique

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Expression cloning of the murine erythropoietin receptor

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Two microsatellite repeat polymorphisms in the EPO gene.

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Primary familial and congenital polycythaemia

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Towards a molecular understanding of polycythemia rubra vera

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Polycythemia vera: stem-cell and probable clonal origin of the disease

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Diagnostic applications of haemopoietic progenitor culture techniques in polycythaemias and thrombocythaemias

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Erythroid colony formation by polycythemia vera bone marrow in vitro. Dependence on erythropoietin

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Polycythemia vera blood burst-forming units-erythroid are hypersensitive to interleukin-3.

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Possible involvement of protein kinase C in the aberrant regulation of erythropoiesis in polycythemia vera

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Protein tyrosine phosphatases in signaling

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

No evidence for an altered mRNA expression or protein level of haematopoietic cell phosphatase in CD34+ bone marrow progenitor cells or mature peripheral blood cells in polycythaemia vera

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

The gene encoding hematopoietic cell phosphatase (SHP-1) is structurally and transcriptionally intact in polycythemia vera

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Defective expression of the SHP-1 phosphatase in polycythemia vera

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Expression of Bcl-x in erythroid precursors from patients with polycythemia vera

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Stimulus-specific defect in platelet aggregation in polycythemia vera

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Studies of neutrophil and monocyte oxidative responses in polycythaemia vera and related myeloproliferative disorders

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Platelet derived growth factor messenger RNA is increased in bone marrow megakaryocytes in patients with myeloproliferative disorders

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

Markedly Reduced Expression of Platelet c-mpl Receptor in Essential Thrombocythemia

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https://api.crossref.org/works/10.1016%2FS0037-1963%2801%2990135-0

7 January 2021

10.1016/S0037-1963(01)90135-0

Identifiers

DOI

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6 July 2017

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PubMed ID

11242597