Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). (Q39121098)

9 September 2017

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). (English)

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9 September 2017

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Dickson LM

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9 September 2017

Lingohr MK

2

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9 September 2017

McCuaig J

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9 September 2017

Hugl SR

4

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9 September 2017

Snow L

5

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9 September 2017

Kahn BB

6

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9 September 2017

Myers MG Jr

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9 September 2017

Rhodes CJ

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9 September 2017

language of work or name

English

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publication date

27 March 2001

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Journal of Biological Chemistry

9 September 2017

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9 September 2017

276

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9 September 2017

24

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9 September 2017

21110-21120

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IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication

9 September 2017

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Disruption of IRS-2 causes type 2 diabetes in mice

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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediat

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1 reference

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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

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Signal transduction mechanism of insulin and insulin-like growth factor-1.

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IGF-I: a mitogen also involved in differentiation processes in mammalian cells

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The IRS-signalling system during insulin and cytokine action

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

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The PI3K-PDK1 connection: more than just a road to PKB

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

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The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin

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Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

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Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

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Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

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A simplified system for generating recombinant adenoviruses

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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

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The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.

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Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

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A signaling pathway to translational control

21 January 2018

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Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

21 January 2018

1 reference

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

1 reference

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.

21 January 2018

1 reference

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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1 reference

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Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

21 January 2018

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

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Mechanism of action of the immunosuppressant rapamycin

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p70 S6 kinase: an enigma with variations

21 January 2018

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The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

21 January 2018

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The modular phosphorylation and activation of p70s6k.

21 January 2018

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Ribosomal S6 kinase signaling and the control of translation

21 January 2018

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TOR signalling and control of cell growth

21 January 2018

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

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Negative regulation of the serine/threonine kinase B-Raf by Akt

21 January 2018

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Cellular survival: a play in three Akts

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Lipid-Regulated Kinases: Some Common Themes at Last

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21 January 2018

Identifiers

DOI

10.1074/JBC.M101257200

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9 September 2017

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