Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes? (Q34750166)

4 August 2017

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title

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes? (English)

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4 August 2017

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Melissa K Lingohr

1

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PubMed ID

12127723

4 August 2017

Roland Buettner

series ordinal

2

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PubMed ID

12127723

4 August 2017

Christopher J Rhodes

series ordinal

3

1 reference

4 August 2017

1 August 2002

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Trends in Molecular Medicine

4 August 2017

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4 August 2017

8

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4 August 2017

8

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4 August 2017

375-384

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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Islet growth and development in the adult

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Molecular insights into insulin action and secretion

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

The continuing epidemics of obesity and diabetes in the United States

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Global and societal implications of the diabetes epidemic

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Type 2 diabetes in children and adolescents: an emerging disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

The beta cell transcription factors and development of the pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Diseases of liporegulation: new perspective on obesity and related disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediat

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5).

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Growth hormone is a growth factor for the differentiated pancreatic beta-cell

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Number and size of islets of Langerhans in pregnant, human growth hormone-expressing transgenic, and pituitary dwarf mice: effect of lactogenic hormones

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Effects of platelet-derived growth factor and somatomedin-C/insulin-like growth factor I on the deoxyribonucleic acid replication of fetal rat islets of Langerhans in tissue culture

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Factors controlling pancreatic cell differentiation and function.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Transgenic expression of epidermal growth factor and keratinocyte growth factor in beta-cells results in substantial morphological changes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Effects of vascular endothelial growth factor on pancreatic duct cell replication and the insulin production of fetal islet-like cell clusters in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Growth hormone in obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Regulation of beta-cell mass by hormones and growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Mechanism of signaling by growth hormone receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

IGF-I: a mitogen also involved in differentiation processes in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

The IRS-signalling system: a network of docking proteins that mediate insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Signal transduction mechanisms in nutrient-induced insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Mammalian TOR: a homeostatic ATP sensor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

New drug targets for type 2 diabetes and the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Pathogenesis of insulin resistance: modulation of the insulin signal at receptor level

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

beta-cell apoptosis: stimuli and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Modulation of insulin secretion by cyclic AMP and prostaglandin E: The effects of theophylline, sodium salicylate and tolbutamide

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902377-8

7 January 2021

10.1016/S1471-4914(02)02377-8

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12127723