A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth (Q33200962)

23 July 2017

title

A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth (English)

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23 July 2017

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8

George Q Daley

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Joan Brugge

9

object named as

Joan S Brugge

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23 July 2017

Stuart S Martin

1

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23 July 2017

Alan G Ridgeway

2

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23 July 2017

Jan Pinkas

3

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23 July 2017

Yu Lu

4

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23 July 2017

Mauricio J Reginato

5

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23 July 2017

Eugene Y Koh

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23 July 2017

Montserrat Michelman

7

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23 July 2017

Philip Leder

10

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23 July 2017

language of work or name

English

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publication date

1 June 2004

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23 July 2017

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23 July 2017

volume

23

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23 July 2017

issue

26

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23 July 2017

page(s)

4641-4645

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High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A.

23 July 2017

cites work

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Dissemination and growth of cancer cells in metastatic sites

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Disruption of epithelial cell-matrix interactions induces apoptosis

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Metastatic behavior of human breast carcinomas overexpressing the Bcl-x(L) gene: a role in dormancy and organospecificity.

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From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression

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Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

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Adhesion-mediated signaling in the regulation of mammary epithelial cell survival

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Geometric control of cell life and death

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7 January 2021

Inhibition of apoptosis in human breast cancer cells: role in tumor progression to the metastatic state

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7 January 2021

Establishment of latrunculin-A resistance in HeLa cells by expression of R183A D184A mutant beta-actin

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7 January 2021

Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model

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7 January 2021

BCL-x(L) and BCL2 delay Myc-induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin-dependent kinases

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7 January 2021

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

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7 January 2021

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice.

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7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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7 January 2021

Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2.

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7 January 2021

Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice.

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7 January 2021

Suppression of apoptosis by bcl-2 does not prevent p53-mediated control of experimental metastasis and anchorage dependence

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7 January 2021

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry

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7 January 2021

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

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7 January 2021

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

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7 January 2021

Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

1 reference

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7 January 2021

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207595

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Dimensions Publication ID

23 July 2017

1042667450

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