Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis (Q33201671)

23 July 2017

Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis (English)

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23 July 2017

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Feng Chen

1

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23 July 2017

Onur K Arseven

series ordinal

2

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23 July 2017

Vincent L Cryns

series ordinal

3

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23 July 2017

language of work or name

English

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publication date

15 April 2004

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Journal of Biological Chemistry

23 July 2017

7

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based on heuristic

inferred from page(s)

published in

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23 July 2017

279

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23 July 2017

26

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23 July 2017

27542-27548

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23 July 2017

Caspases: enemies within

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Caspase-10 is an initiator caspase in death receptor signaling

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Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

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Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

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A novel Apaf-1-independent putative caspase-2 activation complex

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

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Endonuclease G is an apoptotic DNase when released from mitochondria

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Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

21 January 2018

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Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans

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Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

21 January 2018

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

21 January 2018

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

21 January 2018

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

21 January 2018

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Caspase proteolysis of the cohesin component RAD21 promotes apoptosis

21 January 2018

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Linking sister chromatid cohesion and apoptosis: role of Rad21.

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Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage

21 January 2018

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Cleavage and inactivation of ATM during apoptosis.

21 January 2018

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Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

21 January 2018

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Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death

21 January 2018

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Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis.

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DNA repair and tumorigenesis: lessons from hereditary cancer syndromes

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Functional interactions and signaling properties of mammalian DNA mismatch repair proteins

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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer.

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Mutation of a mutL homolog in hereditary colon cancer

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Role of DNA mismatch repair defects in the pathogenesis of human cancer

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

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Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells

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The mismatch repair system is required for S-phase checkpoint activation

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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

21 January 2018

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Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

21 January 2018

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

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Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes.

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Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy

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Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis

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The receptor for the cytotoxic ligand TRAIL

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The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation

21 January 2018

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Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

21 January 2018

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Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo

21 January 2018

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Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants

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Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin

21 January 2018

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Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX

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FLICE Induced Apoptosis in a Cell-free System

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Guarding against mutation

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Identifiers

DOI

10.1074/JBC.M400971200

1 reference

23 July 2017

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