Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers (Q33237559)

24 July 2017

Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers (English)

1 reference

single-nucleotide polymorphism

24 July 2017

1 reference

1 reference

Jeremy P Blaydes

3

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Peter Johnson

object named as

Peter W Johnson

5

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Diana Eccles

object named as

Diana M Eccles

6

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author name string

Ellen R Copson

1

1 reference

24 July 2017

Helen E White

2

1 reference

24 July 2017

David O Robinson

4

1 reference

24 July 2017

language of work or name

English

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publication date

24 March 2006

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24 July 2017

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24 July 2017

6

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24 July 2017

1

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29 June 2019

page(s)

80

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https://scigraph.springernature.com/pub.10.1186/1471-2407-6-80

24 July 2017

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cites work

The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck

1 reference

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A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Collaboration of Brca1 and Chk2 in tumorigenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Immunophenotypic and pathologic differences between BRCA1 and BRCA2 hereditary breast cancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Insights into the functions of BRCA1 and BRCA2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

BRCA1 is a component of the RNA polymerase II holoenzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

MDM2 overexpression is rare in ovarian carcinoma irrespective of TP53 mutation status.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group

21 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-80

The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-80

Brca1 required for T cell lineage development but not TCR loci rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-80

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-6-80

No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Regulation of the p53 protein by the MDM2 oncoprotein--thirty-eighth G.H.A. Clowes Memorial Award Lecture.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483833

Abnormal expression of MDM-2 in breast carcinomas

31 October 2018

1 reference

12 December 2020

p53 mutations in BRCA1-associated familial breast cancer

1 reference

12 December 2020

Mammary tumor formation in p53- and BRCA1-deficient mice

1 reference

12 December 2020

Increased frequency ofTP53 mutations inBRCA1 andBRCA2 ovarian tumours

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2407-6-80

1 reference

Dimensions Publication ID

24 July 2017

0 references

1 reference

24 July 2017

1 reference