The 7 TM G-protein-coupled receptor target family (Q33253601)

24 July 2017

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title

The 7 TM G-protein-coupled receptor target family (English)

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G protein-coupled receptor

24 July 2017

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author name string

Edgar Jacoby

1

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24 July 2017

Rochdi Bouhelal

2

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24 July 2017

Marc Gerspacher

3

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24 July 2017

Klaus Seuwen

4

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24 July 2017

1 August 2006

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24 July 2017

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24 July 2017

1

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24 July 2017

8

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24 July 2017

761-782

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

24 July 2017

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7 January 2021

Drug design strategies for targeting G-protein-coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The state of GPCR research in 2004.

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The Frizzled family: receptors for multiple signal transduction pathways

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

GPCRDB information system for G protein-coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Historical review: a brief history and personal retrospective of seven-transmembrane receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Nobel Lecture. Signal transduction: evolution of an idea

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Nobel Lecture. G proteins and regulation of adenylyl cyclase

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Studies on the mechanism of hormone action

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

G-protein-coupled receptors and signaling networks: emerging paradigms.

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The many faces of G protein signaling

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Nobel lecture in physiology or medicine--1988. Drugs from emasculated hormones: the principle of syntopic antagonism.

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Structure of rhodopsin and bacteriorhodopsin

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Three-dimensional model of purple membrane obtained by electron microscopy

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Maximizing serendipity: strategies for identifying ligands for orphan G-protein-coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The identification of ligands at orphan G-protein coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Mechanisms of inverse agonism at G-protein-coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Identification of residues required for ligand binding to the beta-adrenergic receptor

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Molecular Architecture of G Protein-Coupled Receptors.

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Molecular tinkering of G protein-coupled receptors: an evolutionary success

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The G protein-coupled receptor repertoires of human and mouse

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

A novel multigene family may encode odorant receptors: a molecular basis for odor recognition

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

https://api.crossref.org/works/10.1002%2FCMDC.200600134

1 reference

7 January 2021

The repertoire of G-protein-coupled receptors in fully sequenced genomes

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Viral hijacking of G-protein-coupled-receptor signalling networks.

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The use of constitutively active GPCRs in drug discovery and functional genomics

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

High-content assays for ligand regulation of G-protein-coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

High content screening for G protein-coupled receptors using cell-based protein translocation assays.

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Proton-sensing G-protein-coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Crystal structure of rhodopsin: A G protein-coupled receptor

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

This is not a G protein-coupled receptor.

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Modelling G-protein-coupled receptors for drug design

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Recognition of privileged structures by G-protein coupled receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

High-throughput modeling of human G-protein coupled receptors: amino acid sequence alignment, three-dimensional model building, and receptor library screening

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Essential role for the second extracellular loop in C5a receptor activation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Successful virtual screening for a submicromolar antagonist of the neurokinin-1 receptor based on a ligand-supported homology model

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

G protein-coupled receptors: in silico drug discovery in 3D.

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Functional Microdomains in G-protein-coupled Receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Protean agonists. Keys to receptor active states?

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

G protein-coupled receptor dimerization: function and ligand pharmacology

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Structural genomics of GPCRs

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Ligand identification for G-protein-coupled receptors: a lead generation perspective

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The design of screening libraries targeted at G-protein coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Integration of virtual and high-throughput screening

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Pursuing the leadlikeness concept in pharmaceutical research.

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Designing peptide receptor agonists and antagonists

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Chemogenomics with peptide secondary structure mimetics

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Design criteria for molecular mimics of fragments of the beta-turn. 1. C alpha atom analysis

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Design criteria for molecular mimics of fragments of the beta-turn. 2. C alpha-C beta bond vector analysis

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Privileged structure-based combinatorial libraries targeting G protein-coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Combinatorial synthesis of 3-(amidoalkyl) and 3-(aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Finding multiactivity substructures by mining databases of drug-like compounds

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

The properties of known drugs. 1. Molecular frameworks

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Selective optimization of side activities: another way for drug discovery

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Why do we need so many chemical similarity search methods?

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Comparison of topological descriptors for similarity-based virtual screening using multiple bioactive reference structures

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Exploring the chemogenomic knowledge space with annotated chemical libraries

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

GPCR-tailored pharmacophore pattern recognition of small molecular ligands

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

De novo design of molecular architectures by evolutionary assembly of drug-derived building blocks

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

An ontology for pharmaceutical ligands and its application for in silico screening and library design

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

GPCR antitarget modeling: pharmacophore models for biogenic amine binding GPCRs to avoid GPCR-mediated side effects

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Predicting ligands for orphan GPCRs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Bioinformatics approaches for the classification of G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Construction of a sequence motif characteristic of aminergic G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

A physicogenetic method to assign ligand-binding relationships between 7TM receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

An ultra-HTS process for the identification of small molecule modulators of orphan G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

High throughput screening technologies for direct cyclic AMP measurement

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Functional G protein-coupled receptor assays for primary and secondary screening

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

G-protein coupled receptor assays: to measure affinity or efficacy that is the question

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Ligand-selective signaling and high-content screening for GPCR drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Predicting therapeutic value in the lead optimization phase of drug discovery

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Unravelling the unusual signalling properties of the GABA(B) receptor.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

GPCR interacting proteins (GIP).

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Pharmacogenomics--drug disposition, drug targets, and side effects

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Pharmacology and physiology of human adrenergic receptor polymorphisms

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Olfaction: mosquito receptor for human-sweat odorant

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https://api.crossref.org/works/10.1002%2FCMDC.200600134

7 January 2021

Identifiers

DOI

10.1002/CMDC.200600134

1 reference

24 July 2017

1 reference