Inhibitors of c-Jun N-terminal kinases: JuNK no more? (Q33304105)

25 July 2017

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title

Inhibitors of c-Jun N-terminal kinases: JuNK no more? (English)

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25 July 2017

Marie A Bogoyevitch

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Peter G. Arthur

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Peter G Arthur

series ordinal

2

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language of work or name

English

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publication date

11 October 2007

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Biochimica et Biophysica Acta

25 July 2017

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25 July 2017

1784

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25 July 2017

76-93

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25 July 2017

1

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Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes

25 July 2017

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12 December 2020

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes

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12 December 2020

Activation of cJUN N-terminal kinase by herpes simplex virus type 1 enhances viral replication

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12 December 2020

p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes

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12 December 2020

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

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12 December 2020

c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation

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12 December 2020

A small molecule-kinase interaction map for clinical kinase inhibitors

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12 December 2020

Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity.

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12 December 2020

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.

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12 December 2020

Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons

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12 December 2020

Activation of the Jun N-terminal kinase pathway by friend spleen focus-forming virus and its role in the growth and survival of friend virus-induced erythroleukemia cells

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12 December 2020

Therapeutic promise of JNK ATP-noncompetitive inhibitors.

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12 December 2020

Kinetic characterization of human JNK2alpha2 reaction mechanism using substrate competitive inhibitors

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12 December 2020

Functional role of JNK in neuritogenesis of PC12-N1 cells

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12 December 2020

Necrotic death of neurons following an excitotoxic insult is prevented by a peptide inhibitor of c-jun N-terminal kinase

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12 December 2020

The specificities of protein kinase inhibitors: an update

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12 December 2020

Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway

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12 December 2020

Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2

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12 December 2020

Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.

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12 December 2020

SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease

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12 December 2020

Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun

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12 December 2020

The l-isoform but not d-isoforms of a JNK inhibitory peptide protects pancreatic beta-cells

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12 December 2020

ORF36 protein kinase of Kaposi's sarcoma herpesvirus activates the c-Jun N-terminal kinase signaling pathway.

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12 December 2020

Cell-permeable peptides induce dose- and length-dependent cytotoxic effects

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12 December 2020

A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

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12 December 2020

Varicella-zoster virus infection of human fibroblast cells activates the c-Jun N-terminal kinase pathway

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12 December 2020

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond.

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12 December 2020

Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage.

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12 December 2020

JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury.

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12 December 2020

Identification of the critical features of a small peptide inhibitor of JNK activity

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12 December 2020

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

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12 December 2020

Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes

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12 December 2020

Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.

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12 December 2020

SP600125, a selective JNK inhibitor, aggravates hepatic ischemia-reperfusion injury

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12 December 2020

Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion

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12 December 2020

Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor

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12 December 2020

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

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12 December 2020

JNK mediates hepatic ischemia reperfusion injury

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12 December 2020

Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury

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12 December 2020

Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3

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12 December 2020

Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.

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12 December 2020

A cytoplasmic inhibitor of the JNK signal transduction pathway

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12 December 2020

Inhibition of JNK activation prolongs survival after smoke inhalation from fires.

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12 December 2020

Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases

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12 December 2020

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity

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12 December 2020

A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis

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12 December 2020

Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth.

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12 December 2020

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

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12 December 2020

Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.

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12 December 2020

Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase

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12 December 2020

The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity

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12 December 2020

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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12 December 2020

The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways

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12 December 2020

The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis

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12 December 2020

A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.

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12 December 2020

Macrophage-mediated renal injury is dependent on signaling via the JNK pathway

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12 December 2020

SP600125, a selective JNK inhibitor, protects ischemic renal injury via suppressing the extrinsic pathways of apoptosis

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12 December 2020

A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo.

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12 December 2020

Stress-activated protein kinases are involved in coxsackievirus B3 viral progeny release

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12 December 2020

Mitogen-activated protein kinases activate the nuclear localization sequence of human papillomavirus type 11 E1 DNA helicase to promote efficient nuclear import

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12 December 2020

Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors

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12 December 2020

Chemical genetics: where genetics and pharmacology meet

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12 December 2020

D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia

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12 December 2020

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

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12 December 2020

Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury

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12 December 2020

Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats

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12 December 2020

The MAP kinase cascades are activated during post-ischemic liver reperfusion

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12 December 2020

Activated c-Jun N-terminal kinase is required for axon formation.

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12 December 2020

Novel Strategy for Treatment of Viral Central Nervous System Infection by Using a Cell-Permeating Inhibitor of c-Jun N-Terminal Kinase

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12 December 2020

The isoform-specific functions of the c-Jun N-terminal Kinases (JNKs): differences revealed by gene targeting.

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12 December 2020

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

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12 December 2020

The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold

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12 December 2020

JNK and PI3k/Akt signaling pathways are required for establishing persistent SARS-CoV infection in Vero E6 cells.

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12 December 2020

Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster

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12 December 2020

c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons

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12 December 2020

Rotavirus activates JNK and p38 signaling pathways in intestinal cells, leading to AP-1-driven transcriptional responses and enhanced virus replication

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12 December 2020

Inhibition of c-Jun N-terminal kinase rescues influenza epitope-specific human cytolytic T lymphocytes from activation-induced cell death.

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12 December 2020

Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway

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12 December 2020

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

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12 December 2020

Induction of the RelB NF-kappaB subunit by the cytomegalovirus IE1 protein is mediated via Jun kinase and c-Jun/Fra-2 AP-1 complexes

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12 December 2020

Structure-activity studies with cytotoxic anthrapyrazoles.

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12 December 2020

Peptide inhibitors of protein kinases-discovery, characterisation and use

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12 December 2020

TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK.

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12 December 2020

Chemical genetic analysis of the time course of signal transduction by JNK

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12 December 2020

Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase.

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12 December 2020

PAN-811 provides neuroprotection against glutamate toxicity by suppressing activation of JNK and p38 MAPK.

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12 December 2020

Cell death: critical control points

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12 December 2020

Neuroprotection against ischemic brain injury by a small peptide inhibitor of c-Jun N-terminal kinase (JNK) via nuclear and non-nuclear pathways.

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12 December 2020

Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase

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12 December 2020

The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia

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12 December 2020

JNK2 is a positive regulator of the cJun transcription factor

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12 December 2020

The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK.

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12 December 2020

An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins.

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12 December 2020

AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties

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12 December 2020

Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs.

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12 December 2020

Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals.

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12 December 2020

Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.

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12 December 2020

Cytochrome C-mediated apoptosis

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12 December 2020

Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis.

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12 December 2020

Reverse two-hybrid screening identifies residues of JNK required for interaction with the kinase interaction motif of JNK-interacting protein-1.

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12 December 2020

A central role for JNK in obesity and insulin resistance

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12 December 2020

c-Jun N-terminal kinase inhibitor SP600125 modulates the period of mammalian circadian rhythms

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12 December 2020

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

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12 December 2020

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model

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12 December 2020

Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney

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12 December 2020

c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation

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12 December 2020

Modulation of the JNK pathway in liver affects insulin resistance status

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12 December 2020

Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors.

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12 December 2020

Latifolians A and B, Novel JNK3 Kinase Inhibitors from the Papua New Guinean PlantGnetumlatifolium

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12 December 2020

A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.

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12 December 2020

Replication of varicella-zoster virus is influenced by the levels of JNK/SAPK and p38/MAPK activation

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12 December 2020

A Novel 9-Aza-Anthrapyrazole Effective against Human Prostatic Carcinoma Xenografts

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12 December 2020

Phosphorylation of c-jun mediated by MAP kinases.

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12 December 2020

Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.

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12 December 2020

Contribution of the membrane-distal tyrosine in intracellular signaling by the granulocyte colony-stimulating factor receptor

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12 December 2020

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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12 December 2020

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.

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12 December 2020

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

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12 December 2020

10.1016/J.BBAPAP.2007.09.013

Identifiers

DOI

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25 July 2017

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PubMed ID

17964301