Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. (Q33329474)

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6 January 2020

title

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway (English)

1 reference

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6 January 2020

11

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6 January 2020

author name string

J E Kravchenko

1

1 reference

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6 January 2020

G V Ilyinskaya

2

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6 January 2020

P G Komarov

3

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6 January 2020

L S Agapova

4

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6 January 2020

D V Kochetkov

5

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6 January 2020

E Strom

6

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6 January 2020

E I Frolova

7

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6 January 2020

I Kovriga

8

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6 January 2020

A V Gudkov

9

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6 January 2020

E Feinstein

10

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6 January 2020

language of work or name

English

0 references

publication date

18 April 2008

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

6 January 2020

published in

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6 January 2020

volume

105

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6 January 2020

page(s)

6302-6307

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6 January 2020

issue

17

1 reference

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A novel role for p73 in the regulation of Akt-Foxo1a-Bim signaling and apoptosis induced by the plant lectin, Concanavalin A.

6 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

p73: a chiaroscuro gene in cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

One, two, three--p53, p63, p73 and chemosensitivity.

21 June 2018

1 reference

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ASPP: a new family of oncogenes and tumour suppressor genes

21 June 2018

1 reference

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Regulating p73 isoforms in human tumours

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

The antioxidant function of the p53 tumor suppressor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

P73 functionally replaces p53 in Adriamycin-treated, p53-deficient breast cancer cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2327210

Chemosensitivity linked to p73 function

21 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18424558

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18424558

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0802091105

1 reference

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6 January 2020

0 references

1 reference

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6 January 2020

1 reference