A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials (Q33330310)

25 July 2017

title

A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials (English)

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25 July 2017

Satyaprakash Nayak

1

1 reference

25 July 2017

Saniya Salim

2

1 reference

25 July 2017

Deyan Luan

3

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25 July 2017

Michael Zai

4

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25 July 2017

Jeffrey D Varner

5

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25 July 2017

language of work or name

English

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publication date

23 April 2008

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25 July 2017

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25 July 2017

volume

3

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25 July 2017

issue

4

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25 July 2017

page(s)

e2016

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Creative Commons Attribution 4.0 International

25 July 2017

copyright license

start time

23 April 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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21 June 2018

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Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

21 June 2018

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A quantitative analysis of the kinetics of the G(2) DNA damage checkpoint system

21 June 2018

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Instabilities in phosphorylation-dephosphorylation cascades and cell cycle checkpoints

21 June 2018

1 reference

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Robustness in bacterial chemotaxis

21 June 2018

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Cyclin D1 and human neoplasia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Human brain tumor xenografts in nude mice as a chemotherapy model

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Cyclin is degraded by the ubiquitin pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291571

Evolutionary design on a budget: robustness and optimality of bacteriophage T7.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise.

21 January 2018

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A robustness-based approach to systems-oriented drug design.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Regulation of the mammalian cell cycle: a model of the G1-to-S transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

A model for restriction point control of the mammalian cell cycle.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

The kinetic origins of the restriction point in the mammalian cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Missing the target: ubiquitin ligase drugs stall

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Mouse development and cell proliferation in the absence of D-cyclins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Isochron-based phase response analysis of circadian rhythms

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Phase sensitivity analysis of circadian rhythm entrainment

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

An efficient k-means clustering algorithm: analysis and implementation

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002016

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

21 January 2018

1 reference

12 December 2020

PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo

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12 December 2020

Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma

1 reference

12 December 2020

The two-hybrid system: an assay for protein-protein interactions

1 reference

12 December 2020

Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2

1 reference

12 December 2020

Deregulation of cyclin E in breast cancer

1 reference

12 December 2020

Activity of rapamycin (AY-22,989) against transplanted tumors

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0002016

Identifiers

DOI

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25 July 2017

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25 July 2017

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