Drug discovery in the ubiquitin-proteasome system. (Q36525810)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

review article

1 reference

title

Drug discovery in the ubiquitin-proteasome system (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

ubiquitin-proteasome system

26 December 2019

main subject

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

Jeffrey W. Harper

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

author name string

Mark Rolfe

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

publication date

1 July 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

26 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

page(s)

596-613

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16816840%20AND%20SRC:MED&resulttype=core&format=json

Back to the future with ubiquitin

26 December 2019

cites work

1 reference

Basic Medical Research Award. The ubiquitin system

31 March 2020

1 reference

Interwoven ubiquitination oscillators and control of cell cycle transitions

31 March 2020

1 reference

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

31 March 2020

1 reference

CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer.

31 March 2020

1 reference

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

31 March 2020

1 reference

Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer.

31 March 2020

1 reference

Molecular pathogenesis of Parkinson's disease

31 March 2020

1 reference

Genetics of Parkinson's disease

31 March 2020

1 reference

Parkinson's disease: mechanisms and models

31 March 2020

1 reference

Genetic clues to the pathogenesis of Parkinson's disease

31 March 2020

1 reference

Ubiquitin, proteasome and parkin

31 March 2020

1 reference

Prognostic relevance of gene amplifications and coamplifications in breast cancer

31 March 2020

1 reference

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

31 March 2020

1 reference

MDM2 gene amplification in bone and soft‐tissue tumors: Association with tumor progression in differentiated adipose‐tissue tumors

31 March 2020

1 reference

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

31 March 2020

1 reference

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

31 March 2020

1 reference

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

31 March 2020

1 reference

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

31 March 2020

1 reference

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

31 March 2020

1 reference

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

31 March 2020

1 reference

Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

31 March 2020

1 reference

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

31 March 2020

1 reference

Skp2-mediated degradation of p27 regulates progression into mitosis

31 March 2020

1 reference

A genomic and functional inventory of deubiquitinating enzymes

31 March 2020

1 reference

Stabilization of beta-catenin by genetic defects in melanoma cell lines

31 March 2020

1 reference

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

31 March 2020

1 reference

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

31 March 2020

1 reference

The development of proteasome inhibitors as anticancer drugs

31 March 2020

1 reference

The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications

31 March 2020

1 reference

Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies

31 March 2020

1 reference

A phase 2 study of bortezomib in relapsed, refractory myeloma

31 March 2020

1 reference

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

31 March 2020

1 reference

Therapeutic anti-cancer targets upstream of the proteasome.

31 March 2020

1 reference

31 March 2020

1 reference

Mechanisms underlying ubiquitination

31 March 2020

1 reference

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

31 March 2020

1 reference

Structure of ubiquitin refined at 1.8 A resolution

31 March 2020

1 reference

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

31 March 2020

1 reference

31 March 2020

1 reference

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8

31 March 2020

1 reference

Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1

31 March 2020

1 reference

Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1

31 March 2020

1 reference

31 March 2020

1 reference

Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia

31 March 2020

1 reference

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

31 March 2020

1 reference

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

31 March 2020

1 reference

Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.

31 March 2020

1 reference

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

31 March 2020

1 reference

U box proteins as a new family of ubiquitin-protein ligases

31 March 2020

1 reference

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

31 March 2020

1 reference

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

31 March 2020

1 reference

Function and regulation of cullin-RING ubiquitin ligases

31 March 2020

1 reference

RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer

31 March 2020

1 reference

Therapeutic exploitation of the p53 pathway

31 March 2020

1 reference

Activation and activities of the p53 tumour suppressor protein

31 March 2020

1 reference

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

31 March 2020

1 reference

Live or let die: the cell's response to p53

31 March 2020

1 reference

MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

31 March 2020

1 reference

Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms

31 March 2020

1 reference

Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level

31 March 2020

1 reference

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

31 March 2020

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

1 reference

Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines

31 March 2020

1 reference

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

31 March 2020

1 reference

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

31 March 2020

1 reference

DNA damage activates p53 through a phosphorylation-acetylation cascade

31 March 2020

1 reference

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

31 March 2020

1 reference

NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

31 March 2020

1 reference

In vitro induction of sister-chromatid exchanges after G0 exposure of human lymphocytes to five naphthofurans

31 March 2020

1 reference

7-Methoxy-2-nitronaphtho[2,1-b]furan (R7000)-induced mutation spectrum in the lacI gene of Escherichia coli: influence of SOS mutagenesis.

31 March 2020

1 reference

DNA damage induced in vivo by 7-methoxy-2-nitronaphtho[2,1-b]-furan (R7000) in the lacI gene of Escherichia coli.

31 March 2020

1 reference

Mutagenic properties of a nitrofuran, 7-methoxy-2-nitronaphtho[2, 1-b]furan (R7000), in lacI transgenic mice.

31 March 2020

1 reference

Molecular pathways to neurodegeneration

31 March 2020

1 reference

Molecular Pathways of Neurodegeneration in Parkinson's Disease

31 March 2020

1 reference

Genetics of Parkinson disease: paradigm shifts and future prospects.

31 March 2020

1 reference

Are ubiquitination pathways central to Parkinson's disease?

31 March 2020

1 reference

How does parkin ligate ubiquitin to Parkinson's disease?

31 March 2020

1 reference

Clinical practice. Diagnosis and initial management of Parkinson's disease

31 March 2020

1 reference

The diagnosis of Parkinson's disease

31 March 2020

1 reference

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

31 March 2020

1 reference

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

31 March 2020

1 reference

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

31 March 2020

1 reference

Parkin counteracts symptoms in a Drosophila model of Parkinson's disease

31 March 2020

1 reference

Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease

31 March 2020

1 reference

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

31 March 2020

1 reference

SCF-mediated protein degradation and cell cycle control

31 March 2020

1 reference

Systematic analysis and nomenclature of mammalian F-box proteins

31 March 2020

1 reference

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

31 March 2020

1 reference

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

31 March 2020

1 reference

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

31 March 2020

1 reference

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

31 March 2020

1 reference

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

31 March 2020

1 reference

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

31 March 2020

1 reference

SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells

31 March 2020

1 reference

31 March 2020

1 reference

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

31 March 2020

1 reference

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

31 March 2020

1 reference

31 March 2020

Skp2, the FoxO1 hunter

1 reference

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

31 March 2020

1 reference

Skp2 is oncogenic and overexpressed in human cancers

31 March 2020

1 reference

In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation

31 March 2020

1 reference

Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference

31 March 2020

1 reference

RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells

31 March 2020

1 reference

Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo

31 March 2020

1 reference

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

31 March 2020

1 reference

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

31 March 2020

1 reference

Inactivation of hCDC4 can cause chromosomal instability

31 March 2020

1 reference

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

31 March 2020

1 reference

The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

31 March 2020

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

31 March 2020

1 reference

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

31 March 2020

1 reference

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

31 March 2020

1 reference

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

31 March 2020

1 reference

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

31 March 2020

1 reference

Heat shock protein 90 as a molecular target for cancer therapeutics

31 March 2020

1 reference

The U box is a modified RING finger — a common domain in ubiquitination

31 March 2020

1 reference

Structural insights into the U-box, a domain associated with multi-ubiquitination

31 March 2020

1 reference

U-box proteins as a new family of ubiquitin ligases

31 March 2020

1 reference

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

31 March 2020

1 reference

ErbB2 degradation mediated by the co-chaperone protein CHIP

31 March 2020

1 reference

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

31 March 2020

1 reference

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

31 March 2020

1 reference

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

31 March 2020

1 reference

Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney

31 March 2020

1 reference

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

31 March 2020

1 reference

Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein.

31 March 2020

1 reference

UBE3A/E6-AP mutations cause Angelman syndrome

31 March 2020

1 reference

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

31 March 2020

1 reference

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

31 March 2020

1 reference

Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)

31 March 2020

1 reference

Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

31 March 2020

1 reference

Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex

31 March 2020

1 reference

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

31 March 2020

1 reference

Clinical profile of Angelman syndrome at different ages

31 March 2020

1 reference

Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins

31 March 2020

1 reference

E6AP gene suppression and characterization with in vitro selected hammerhead ribozymes.

31 March 2020

1 reference

Zn(2+) fingers and cervical cancer

31 March 2020

1 reference

Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial

31 March 2020

1 reference

Prophylactic human papillomavirus vaccines

31 March 2020

1 reference

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

31 March 2020

1 reference

Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation

31 March 2020

1 reference

Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins

31 March 2020

1 reference

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome

31 March 2020

1 reference

Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases

31 March 2020

1 reference

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

31 March 2020

1 reference

COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases

31 March 2020

1 reference

31 March 2020

1 reference

JAMM: a metalloprotease-like zinc site in the proteasome and signalosome

31 March 2020

1 reference

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

31 March 2020

1 reference

Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system

31 March 2020

1 reference

Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.

31 March 2020

1 reference

A superfamily of protein tags: ubiquitin, SUMO and related modifiers

31 March 2020

1 reference

Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis

31 March 2020

1 reference