Ubiquitin ligases: cell-cycle control and cancer (Q29617992)

Europe PubMed Central

title

Ubiquitin ligases: cell-cycle control and cancer (English)

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30 April 2017

author name string

Nakayama KI

series ordinal

1

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Nakayama K

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16633365

30 April 2017

language of work or name

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30 April 2017

publication date

May 2006

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30 April 2017

published in

Nature Reviews Cancer

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volume

6

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page(s)

369-81

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issue

5

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Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

30 April 2017

cites work

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Cyclin is degraded by the ubiquitin pathway

31 March 2020

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Ubiquitin: Roles in protein modification and breakdown

31 March 2020

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Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

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Regulation of the cell cycle by SCF-type ubiquitin ligases

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The anaphase-promoting complex: it's not just for mitosis any more.

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The anaphase-promoting complex: a key factor in the regulation of cell cycle

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Systematic analysis and nomenclature of mammalian F-box proteins

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Cdh1-APC/C, cyclin B-Cdc2, and Alzheimer's disease pathology

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Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

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Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

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Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

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p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

31 March 2020

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Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

31 March 2020

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Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

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Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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Skp2-mediated degradation of p27 regulates progression into mitosis.

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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

31 March 2020

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A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

31 March 2020

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Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes

31 March 2020

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Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes.

31 March 2020

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Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma.

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The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma

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Role of the F-box protein Skp2 in lymphomagenesis

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Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

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Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

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Structure and expression of the gene encoding mouse F-box protein, Fwd2.

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Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

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Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase

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Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle

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Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

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Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

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Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

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Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

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Deregulated cyclin E induces chromosome instability

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Inactivation of hCDC4 can cause chromosomal instability

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Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer.

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Transcriptional regulation and transformation by Myc proteins

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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

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Skp2 regulates Myc protein stability and activity

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The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

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Multiple niches for Notch in cancer: context is everything

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Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

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Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

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Notch signaling in mammary gland tumorigenesis

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Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice

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Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

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The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4).

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Molecular targets of the oncogenic transcription factor jun.

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A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs

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Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity

31 March 2020

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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

31 March 2020

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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

31 March 2020

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Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases

31 March 2020

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.

31 March 2020

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Saccharomyces cerevisiae cdc15 mutants arrested at a late stage in anaphase are rescued by Xenopus cDNAs encoding N-ras or a protein with beta-transducin repeats

31 March 2020

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Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene

31 March 2020

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Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha

31 March 2020

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APC/CTNNB1 (?-catenin) pathway alterations in human prostate cancers

31 March 2020

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Elevated expression of Wnt antagonists is a common event in hepatoblastomas

31 March 2020

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Associations Among -TrCP, an E3 Ubiquitin Ligase Receptor, -Catenin, and NF- B in Colorectal Cancer

31 March 2020

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Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor

31 March 2020

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Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells

31 March 2020

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Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis

31 March 2020

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Overexpression of human beta TrCP1 deleted of its F box induces tumorigenesis in transgenic mice

31 March 2020

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The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila.

31 March 2020

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Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex

31 March 2020

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D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p

31 March 2020

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Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

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Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast

31 March 2020

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Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin

31 March 2020

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The spindle checkpoint, aneuploidy, and cancer

31 March 2020

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hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG

31 March 2020

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Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

31 March 2020

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Securin is required for chromosomal stability in human cells

31 March 2020

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Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation

31 March 2020

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Calcium elevation at fertilization coordinates phosphorylation of XErp1/Emi2 by Plx1 and CaMK II to release metaphase arrest by cytostatic factor.

31 March 2020

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Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells

31 March 2020

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The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis.

31 March 2020

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Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

31 March 2020

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Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

31 March 2020

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The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation

31 March 2020

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Men and sin: what's the difference?

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Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN.

31 March 2020

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The mitotic exit and septation initiation networks

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At the interface between signaling and executing anaphase--Cdc14 and the FEAR network

31 March 2020

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Alterations of anaphase-promoting complex genes in human colon cancer cells

31 March 2020

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Overexpression of B-type cyclins alters chromosomal segregation

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CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

31 March 2020

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Geminin, an inhibitor of DNA replication, is degraded during mitosis

31 March 2020

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The cellular geography of aurora kinases

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Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

31 March 2020

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

31 March 2020

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Amplification/overexpression of a mitotic kinase gene in human bladder cancer

31 March 2020

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Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

31 March 2020

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Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non‐Hodgkin's lymphoma

31 March 2020

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

31 March 2020

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Polo-like kinases (Plks) and cancer

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The Nek2 protein kinase: a novel regulator of centrosome structure

31 March 2020

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies

31 March 2020

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Rationale for the treatment of solid tumors with the proteasome inhibitor bortezomib

31 March 2020

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Skp2 and Jab1 expression are associated with inverse expression of p27(KIP1) and poor prognosis in oral squamous cell carcinomas

31 March 2020

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Oropharyngeal cancer pathogenesis: ubiquitin proteolytic, apoptotic and epidermal growth factor related pathways act in concert--first report.

31 March 2020

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Skp2 is oncogenic and overexpressed in human cancers

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Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

31 March 2020

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Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers

31 March 2020

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Skp2 gene copy number aberrations are common in non-small cell lung carcinoma, and its overexpression in tumors with ras mutation is a poor prognostic marker

31 March 2020

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Immunohistochemical study of Skp2 and Jab1, two key molecules in the degradation of P27, in lung adenocarcinoma

31 March 2020

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Regulation of p27 by S-phase kinase-associated protein 2 is associated with aggressiveness in non-small-cell lung cancer

31 March 2020

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Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship

31 March 2020

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Inverse relationship between p27/Kip.1 and the F-box protein Skp2 in human astrocytic gliomas by immunohistochemistry and Western blot

31 March 2020

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Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas

31 March 2020

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Biological significance of p27 and Skp2 expression in renal cell carcinoma. A systematic analysis of primary and metastatic tumour tissues using a tissue microarray technique

31 March 2020

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Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer

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Expression of p27 and its ubiquitin ligase subunit Skp2 in upper urinary tract transitional cell carcinoma

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Overexpression of Skp2 in carcinoma of the cervix does not correlate inversely with p27 expression

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Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium

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Over-expression of p45(SKP2) in Kaposi's sarcoma correlates with higher tumor stage and extracutaneous involvement but is not directly related to p27(KIP1) down-regulation

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Skp2 protein expression in soft tissue sarcomas

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S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase

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Prognostic significance of the F-box protein Skp2 expression in diffuse large B-cell lymphoma

31 March 2020

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Elevated S-phase kinase-associated protein 2 protein expression in acute myelogenous leukemia: its association with constitutive phosphorylation of phosphatase and tensin homologue protein and poor prognosis

31 March 2020

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Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index

31 March 2020

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Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

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Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma

31 March 2020

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Alterations in cell cycle genes in early stage lung adenocarcinoma identified by expression profiling

31 March 2020

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Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

866463

1030229479

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866463

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16633365

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30 April 2017

Consolidated OpenCitations Corpus – April 2017